No. 2 Duke is one of the highest remaining seeds left in the 2022 NCAA Tournament, but a deep March Madness run won’t be easy in Mike Krzyzewski’s last season. The Blue Devils aren’t among the favorites to win the national championship, and the odds are against them in the Sweet Sixteen.

Duke is the only team that is an underdog against a lower seed in its Sweet Sixteen matchup. No. 3 Texas Tech is favored by 1.5 points over Duke Thursday, according to the latest odds at BetMGM. The winner will go on to face either No. 1 Gonzaga or No. 4 Arkansas in the Elite Eight.

If the Blue Devils get by the Red Raiders, it will likely set up a contest between Gonzaga and Duke in the West Regional Final. Gonzaga is the top overall seed in the NCAA Tournament and would be favored over Duke in a meeting Saturday night.

Duke beat Gonzaga 84-81 early in the college basketball season on a neutral court. Paolo Banchero led the Blue Devils with 21 points.

Duke has +400 odds at BetMGM to make the Final Four. Half of the Sweet Sixteen teams are given a better chance than Duke to win their region.

With +1400 odds to win the NCAA Tournament, eight teams are given worse national championship odds than Duke.

In the first round, Duke had no trouble beating No. 15 Cal State Fullerton 78-61. Duke defeated No. 7 Michigan State 85-76 in a second-round game that came down to the final two minutes.

Banchero is averaging 18.0 points, 8.5 rebounds and 4.0 assists per game in March Madness. Center Mark Williams is putting up 15.0 points, 7.5 rebounds and 5.0 blocks per game while shooting 81.3% from the field.

Duke reached the Elite Eight in both 2018 and 2019. The Blue Devils won their last championship in 2015.

Krzyzewski has more wins than any coach in college basketball history to go along with five national titles and a record 12 Final Four appearances.

Duke Mike Krzyzewski
Pictured: Head coach Mike Krzyzewski of the Duke Blue Devils shouts against the Rhode Island Rams during the second half in the second round of the 2018 NCAA Men's Basketball Tournament at PPG PAINTS Arena on March 17, 2018 in Pittsburgh. Justin K. Aller/Getty Images