The Philadelphia Eagles, New England Patriots and New Orleans Saints all have a chance to hand a 3-0 team their first loss. The Houston Texans and Chicago Bears will each host a quarterback that must prove that he can beat good teams on the road.

There’s no such thing as a “sure thing” when it comes to gambling, but here are the five best bets against the spread for Week 4 of the 2019 NFL season. These are the betting odds from the Westgate Las Vegas Super Contest.

Philadelphia Eagles (+4)

The Eagles are 4-0 on Thursday night games under head coach Doug Pederson. Don’t be surprised if they remain perfect in that spot, in addition to covering the spread, when they visit the Green Bay Packers to kick off Week 4.

The Packers have overcome their offensive struggles to earn a 3-0 record, defeating Mitchell Trubisky, Kirk Cousins and Joe Flacco. Carson Wentz will provide a different challenge to a Green Bay defense that has been terrific but might be ready to come back to earth for at least one game. Philadelphia is getting healthier after two close losses with Alshon Jeffery and Dallas Goedert returning to the lineup.

New England Patriots (-7)

The Buffalo Bills are the worst 3-0 team in the NFL. New England will prove that they still have no competition in the AFC East by beating Buffalo comfortably on the road.

Buffalo still hasn’t beaten a quarterback that has a win this year, going undefeated against Sam Darnold, Eli Manning and Andy Dalton. The Bills needed fourth-quarterback comebacks to defeat the Jets and Bengals. New England hasn’t played any good teams either, but it’s clear the Patriots are the NFL’s best team. The Patriots have outscored their opponents by 89 points. Seven of their last eight wins, including the Super Bowl, have come by double digits.

Tom Brady Patriots
Tom Brady #12 of the New England Patriots gestures in the second half against the Kansas City Chiefs during the AFC Championship Game at Arrowhead Stadium on January 20, 2019 in Kansas City, Missouri. Ronald Martinez/Getty Images

Houston Texans (-4.5)

Let’s see if Kyle Allen can repeat what he did last week when he threw four touchdown passes in place of Cam Newton. The Carolina Panthers’ quarterback could be in for a major regression on the road against Houston.

Expect Deshaun Watson to keep putting up big numbers and potentially enter the fringe of the MVP conversation. The quarterback has a 108.6 passer rating, and he’s made some big plays down the stretch in games on the road against the Saints and Chargers. The Panthers aren’t as good as either one of those teams. Carolina might be lucky to keep this within a touchdown.

Chicago Bears (-1.5)

Until Kirk Cousins starts beating good teams on the road, the right move is to fade him and the Minnesota Vikings. After beating their NFC North rivals twice in 2018, the Bears should take care of business at home against the Vikings in their first 2019 matchup.

Cousins’ career record against winning teams dropped to 5-25 last season with five straight losses to teams that finished above .500. The quarterback was awful in Minnesota’s one matchup this season with a good team, going 14-32 for 230 yards and three turnovers in Green Bay. Khalil Mack and Chicago’s pass rush will feast on a shaky Minnesota offensive line. The Vikings are 1-5 against the spread in their last six games with the Bears, according to OddsShark.

New Orleans Saints (+2.5)

Even without Drew Brees, the Saints are going to be very hard to beat at home. New Orleans has a great chance to upset the visiting Dallas Cowboys as home underdogs.

Dallas might very well be a top Super Bowl contender, but they’ve got something to prove after playing the easiest schedule of anyone. The Cowboys’ offense has looked great against the NFL’s three worst defenses. Dak Prescott won’t look like an MVP candidate against a Saints’ defense that just kept the Seahawks in check in Seattle. Teddy Bridgewater will continue to do a good job of avoiding mistakes and allowing Alvin Kamara to make big plays.

Season Record: 5-10