The Houston Texans, San Francisco 49ers and Baltimore Ravens are all good bets as favorites in the Week 12 primetime games. The Seattle Seahawks and New England Patriots headline the top Sunday afternoon matchups.

There’s no such thing as a “sure thing” when it comes to gambling, but here are the five best bets against the spread for Week 12 of the 2019 NFL season. These are the betting odds from the Westgate Las Vegas Super Contest.

Houston Texans (-4)

The Texans are the best team in the AFC South. Houston should beat the Indianapolis Colts at home Thursday night, making them the heavy favorites to win the division.

Deshaun Watson will bounce back from the subpar performance he had against the Ravens. After getting sacked six times, Watson won’t face that same kind of pressure from the Colts. Jacoby Brissett has come back down to earth with a passer rating below 86.0 in four of his last five starts. Marlon Mack is out. T.Y. Hilton is questionable with a calf injury that’s kept him out since Oct. 27. Indianapolis is 22nd in yards per play and unlikely to keep pace with Houston’s offense.

Seattle Seahawks (+2)

The Seahawks are three games ahead of the Philadelphia Eagles in the standings. Seattle is the easy pick as an underdog against a lesser team.

Philadelphia is 0-2 at home when hosting teams with a good quarterback. Russell Wilson has easily been the NFC’s best signal caller, leading the league with a 114.9 passer rating and 23 touchdowns. The Eagles’ defense hasn’t proven itself against a top offense. Carson Wentz has been a disappointment with a 91.4 passer rating. The Seahawks are 5-0 on the road and 9-0 against the spread in their last nine games as an underdog.

New England Patriots (-6.5)

The Patriots are virtually unbeatable at Gillette Stadium. The Dallas Cowboys won’t be the team that end’s New England’s run of home dominance.

New England has won 20 straight games in Foxborough and nine consecutive home games by double digits. Patrick Mahomes and the Chiefs were the last team to even come close to beating the Patriots on the road. As well as Dak Prescott and the Cowboys’ offense have played, Dallas has struggled against good teams. New England’s defense is the best in the NFL. Tom Brady should find some success against a Dallas defense that has played poorly in recent weeks.

Tom Brady New England Patriots
Tom Brady #12 of the New England Patriots gestures in the second half against the Kansas City Chiefs during the AFC Championship Game at Arrowhead Stadium on January 20, 2019 in Kansas City, Missouri. Ronald Martinez/Getty Images

San Francisco 49ers (-3.5)

The 49ers still have the best defense in the NFC. Aaron Rodgers and the Green Bay Packers will struggle on the road in a low-scoring game.

Green Bay has played two good defenses on the road, scoring only 10 points in Chicago and 11 points in a loss to the Chargers. The Packers’ first loss came in Week 4 when they couldn’t stop the Eagles on the ground. San Francisco’s second-ranked rushing attack will dominate this game. Jimmy Garoppolo won’t be asked to go throw-for-throw with Rodgers, and he’ll be good enough against a defense that ranks 28th in opponents’ yards per play.

Baltimore Ravens (-3)

The Los Angeles Rams don’t have the offensive firepower to keep up with the Ravens. Lamar Jackson’s MVP candidacy could get even stronger in a road win over the defending NFC champs.

Jackson has completely outplayed Wilson, Brady and Watson during Baltimore’s six-game winning streak. He won’t have trouble besting Jared Goff, who has been among the worst quarterbacks that haven’t missed a start in 2019. Take out wins over the lowly Bengals and Falcons, and Goff has seven touchdown passes and 10 interceptions. Baltimore’s defense is much better than it was in the first month of the season. The Rams scored seven points the last time they hosted a first-place team.

Season Record: 21-31-3