The betting lines for Week 2 of the 2021 NFL season vary at different sportsbooks. Here are the best bets for every game this weekend, using odds at either DraftKings, FanDuel or BetMGM

Las Vegas Raiders +6.5 (-115) at Pittsburgh Steelers [DraftKings]

The Raiders are only getting 5.5 points at FanDuel and BetMGM. If Las Vegas’ pass rush continues to shine the way it did in Week 1, this is going to be a very close game.

Cincinnati Bengals (+125) at Chicago Bears [DraftKings]

Chicago began the week as a 3.5-point favorite, and the line has dipped below two points at some sportsbooks. Cincinnati has the much better quarterback, giving the Bengals a strong chance to win outright.

Houston Texans at Cleveland Browns Over 47.5 (-110) [DraftKings and BetMGM]

The bettings odds are the same across the board with Cleveland favored by 12.5 points and the total at 47.5. FanDuel has juiced the over to-115. The Browns should score a ton of points against a bad Texans’ defense that wasn’t tested in Week 1.

Los Angeles Rams (-186) at Indianapolis Colts [FanDuel]

As 3.5-point favorites, the Rams’ moneyline is at least -190 elsewhere. The Seahawks won with ease in Indianapolis, and Los Angeles could have a similar one-sided victory. 

Miami Dolphins +3.5 (-110) vs. Buffalo Bills [BetMGM]

The race for the AFC East title might be much tighter than the preseason odds indicated. Miami has the defense and offensive playmakers to potentially upset Buffalo.

New England Patriots -5.5 (-110) at New York Jets [FanDuel]

It makes sense that the betting line is up to six points at various sportsbooks. The Patriots have a 10-game winning streak against the Jets with eight victories of at least seven points. Zach Wilson is in trouble against Bill Belichick’s defense.

San Francisco 49ers -3 (-105) at Philadelphia Eagles [DraftKings]

The point spread would’ve been much closer to a touchdown if the game were played on opening weekend. There’s not yet enough evidence to show that the Eagles can compete with the 49ers.

Carolina Panthers +3.5 (-106) vs. New Orleans Saints [FanDuel] 

Both DraftKings and BetMGM have the Panthers getting 3.5 points at -110. The Saints won’t play nearly as well as they did in their 38-3 Week 1 win.

Denver Broncos -5.5 (-115) at Jacksonville Jaguars [FanDuel]

Denver is favored by six points at other sportsbooks, following their Week 1 road win against the Giants. The Jaguars are on a 16-game losing streak.

Minnesota Vikings +3.5 (-110) at Arizona Cardinals [All Sportsbooks]

The Vikings can certainly keep this within a field goal, or even steal a win in Arizona. Minnesota probably would be 1-0 if not for a bad fumble call. The Cardinals are not as good as they looked in their 38-13 drubbing of the Titans.

Atlanta Falcons +12.5 (-110) at Tampa Bay Buccaneers [DraftKings] 

Atlanta can cover a 12.5-point spread in a shootout, even if it comes in garbage time. Tampa Bay’s injuries in the secondary could give the Falcons opportunities to move the ball through the air.

Dallas Cowboys +165 at Los Angeles Chargers [DraftKings] 

The Cowboys can outscore the Chargers, even if it takes close to 40 points to do so. Dak Prescott looks healthy and ready to challenge the single-season passing record. 

Tennessee Titans +6 (-110)at Seattle Seahawks [DraftKings]

The line is 5.5 at BetMGM and FanDuel. The Titans can only get better offensively after an uncharacteristically poor performance in Week 1. The Seahawks have a habit of playing in nail-biters 

Kansas City Chiefs -175 at Baltimore Ravens [BetMGM]

The Chiefs were a steal when they opened as 2.5-point favorites, but the line has since moved north of a field goal. Patrick Mahomes is 3-0 against Lamar Jackson and the Ravens, throwing for 1,136 yards, nine touchdowns and one interception in those games.

Detroit Lions +475 at Green Bay Packers [BetMGM]

Green Bay absolutely should bounce back and win this game, though laying 11.5 points would be tough.  It’s at least possible that, with some luck, the Lions could upset the Packers, whom they’ve played competitively in recent seasons. Detroit nearly had a miraculous comeback in Week 1.

Patrick Mahomes Chiefs Ravens Patrick Mahomes #15 of the Kansas City Chiefs points out defensive formations by the Baltimore Ravens at Arrowhead Stadium on September 22, 2019 in Kansas City, Missouri. Photo: David Eulitt/Getty Images