Five road underdogs won straight up on the third Sunday of the 2021 NFL season. A few road teams are capable of pulling off surprise victories against divisional opponents in Week 4. 

Here are the best upset picks for Week 4 with betting odds from FanDuel Sportsbook.

Arizona Cardinals (+220) at Los Angeles Rams

The odds should be closer in a matchup between two of the NFL’s five remaining undefeated teams. Los Angeles has the more impressive resume after beating the Super Bowl champion Buccaneers in convincing fashion, but Arizona looks like a legitimate contender in the NFC West.

If it wasn’t for a historic kick return off a missed field goal, the Cardinals would be coming off a three-touchdown victory in Jacksonville. Arizona completely dominated the first-place Titans and defeated the Vikings, who boast the No. 4-ranked offense. The Cardinals rank third in total offense and first in points scored. 

Los Angeles’ defense has only been average in its 3-0 start. Kyler Murray has 10 total touchdowns with a ton of big plays through three weeks. If the quarterback can limit his mistakes, the Cardinals have a real chance to win outright.

Detroit Lions (+142) at Chicago Bears 

As bad as Chicago’s offense was with Andy Dalton under center, the unit was even worse with Justin Fields at quarterback in Week 3. The winless Lions have at least been competitive to start the season, and they might be on the cusp of pulling off their first victory of 2021.

Fields was sacked nine times in his first start and Chicago was limited to 47 yards of total offense. The rookie was just 14-35 for 138 yards and no passing touchdowns. Whether Fields, Dalton or Nick Foles gets the start, the Lions will have the best quarterback on the field. Chicago’s offense hasn’t been responsible for more than 14 points in any game. 

Detroit’s defense finally gets a reprieve after facing the 49ers, Packers and Ravens to start the season. Baltimore, which entered Week 3 as a top-two offense, was held to 19 points against the Lions. Considering Detroit nearly pulled off a pair of upsets as massive underdogs, the Lions are a worthy moneyline bet against an offense that can’t even muster 200 yards per game.

Las Vegas Raiders (+168) at Los Angeles Chargers

There isn’t a bad team in the entire AFC West. The “Monday Night Football” matchup between the Raiders and Chargers is probably a tossup, making Las Vegas a worthwhile bet as an underdog.

Los Angeles’ home-field advantage will be nonexistent. The Raiders are not far away, and Sofi Stadium is expected to be filled with Raiders’ fans. The Chargers’ only loss this season came at home against a very good offensive team, and Las Vegas can score with anyone.

The Raiders might not be a Super Bowl contender, but their 3-0 start is no fluke. Las Vegas has impressive wins against the Ravens and Steelers, and they showed resilience in their Week 3 overtime victory over the Dolphins. Aside from a pick-six, Derek Carr has been just about as good as any quarterback. Carr led the Raiders to a win in Los Angeles a season ago.

Kyler Murray Arizona Cardinals Kyler Murray #1 of the Arizona Cardinals dives into the end zone for a touchdown while avoiding a tackle by Bobby Wagner #54 of the Seattle Seahawks during the third quarter at State Farm Stadium on October 25, 2020 in Glendale, Arizona. Photo: Norm Hall/Getty Images