Some of the most disappointing teams to start the 2022 NFL season are favored to win in Week 4. A few of those favorites are at risk of being upset by opponents that defeated them last year.

Here's a look at three upsets picks on the Week 4 schedule.

Tennessee Titans (+154) at Indianapolis Colts

The Titans and Colts have both played poorly ahead of their AFC South matchup. Indianapolis entered Week 1 as the clear favorite to win the division. The Colts are favored by more than a field goal at FanDuel Sportsbook, even though they've had little success against the Titans in recent years.

Tennessee has won four of its last five meetings with Indianapolis, including a three-game winning streak. The Titans have won those three contests by an average score of 35-24. Ryan Tannehill hasn't played his best football this year, though he's outperformed Matt Ryan. Ryan has a 77.2 passer rating with four interceptions and 12 sacks. The Colts are averaging a league-low 13.3 points per game.

Arizona Cardinals (+105) at Carolina Panthers

The Cardinals finished six games ahead of the Panthers in last year's standings, and both teams enter Week 4 with a 1-2 record. Carolina is a two-point favorite at DraftKings Sportsbook, coming off its first win of the season. After defeating Jameis Winston and the Saints, the Panthers face their toughest test yet.

Arizona hasn't been impressive to start the season, but Kyler Murray is easily the best quarterback to take on the Panthers. Murray single-handedly led the Cardinals' Week 2 comeback victory in Las Vegas. Murray had 314 passing yards in Week 3, but Arizona was defeated by the Rams as it was forced to settle for four field goals. The Cardinals beat the Panthers 34-10 in Week 10 last season.

Houston Texans (+195) vs. Los Angeles Chargers

Houston defeated Los Angeles 41-29 in Week 16 of last season, pulling off one of the biggest upsets of the year. There are signs that history could repeat itself in Week 4, given the injury concerns that are facing the Chargers.

Left tackle Rashawn Slater is out for the year, and pass rusher Joey Bosa could miss multiple games with a groin injury. Cornerback J.C. Jackson and center Corey Linsley didn't play in Week 3 with injuries. Justin Herbert started despite dealing with torn rib cartilage, but he wasn't all that effective in the team's 38-10 loss against the Jaguars. Houston has been competitive in its 0-2-1 start, only being outscored by 10 points in three games.

Ryan Tannehill Tennessee Titans Arizona Cardinals
Ryan Tannehill #17 of the Tennessee Titans runs the ball during the game against the Arizona Cardinals at Nissan Stadium on September 12, 2021 in Nashville, Tennessee. The Cardinals defeated the Titans 38-13. Wesley Hitt/Getty Images