The Seattle Seahawks and New England Patriots both look to maintain their perfect start to the 2020 NFL season when they meet on “Sunday Night Football” in Week 2.

Seattle and New England had two of the more impressive victories on the first NFL Sunday of the year. The Seahawks defeated the Atlanta Falcons 38-25, scoring more points than all but one team. The Patriots didn’t trail for a second in their home opener, beating the Miami Dolphins 21-11 in a contest they controlled the entire way.

Cam Newton played well in his New England debut. Russell Wilson continued to play like the best quarterback in the NFC.

Seattle's edge on offense and at the sport’s most important position could be the difference in Week 2.

The Seahawks are early four-point favorites over the visiting Patriots, according to the betting odds compiled by OddsShark. The over/under is 45.

Wilson ranked second in both passer rating (143.1) and completion percentage (88.6) among Week 1 quarterbacks, throwing for 322 yards, four touchdowns and no interceptions. The signal caller might have been the 2019 MVP had Lamar Jackson not posted historic numbers. This might be the season that Wilson finally wins the award.

Facing Bill Belichick and the Patriots’ defense is certainly a different challenge than playing the Falcons, though Wilson and the Seahawks won’t be easy to stop.

Ryan Fitzpatrick’s three interceptions made up for the fact that New England lost so many key defensive players in the offseason. Wilson was only picked off five times in the 2019 season, and it’s been two years since he had a game with multiple interceptions.

The Seahawks have scored at least 24 points in all three matchups against the Patriots with Wilson under center. Seattle defeated New England 31-24 at Gillette Stadium in the 2016 season, during which New England allowed fewer total points than any other team.

It remains to be seen whether this Patriots’ offense will be much better than last year’s unit, which struggled with Tom Brady at the helm.

Newton brings a new dynamic with the 15 rushes for 75 yards and two touchdowns that he had in Week 1. New England still only ranked 19th out of 28 teams in total offense while facing a Miami defense that finished dead last in points allowed last season. The Patriots’ playmakers remain underwhelming.

Jamal Adams made an immediate impact for Seattle in Week 1. The safety recorded 12 tackles, 2.5 tackles for a loss and a sack in his debut.

After a down year in 2019, Seattle’s defense should be improved in 2020. The Patriots could struggle to move the ball with consistency at CenturyLink Field.

Seattle is 26-9-3 against the spread in night games since 2007, according to OddsShark, including a 16-5-2 ATS record in night games at home since November of that year.

The Seahawks are a top Super Bowl contender. For the first time in two decades, the Patriots probably are not.

Prediction ATS: Seattle over New England, 27-17

Russell Wilson Seattle Seahawks
Russell Wilson #3 of the Seattle Seahawks celebrates with Chris Carson #32 after a touchdown against the Atlanta Falcons at Mercedes-Benz Stadium on September 13, 2020 in Atlanta, Georgia. Kevin C. Cox/Getty Images