At least one championship is likely to change hands at UFC 270, according to the latest betting odds. Two titles are on the line for Saturday’s fight card, and the challenger is favored in the main event.

UFC heavyweight champion Francis Ngannou takes on interim champion Ciryl Gane in the biggest fight at the pay-per-view in Anaheim, California. Ngannou opened as a slight betting favorite, but that has changed with most of the money being bet on Gane.

As of Thursday afternoon, Gane has -150 odds at BetMGM with 65% of the betting handle to win the heavyweight fight. Ngannou is a +125 underdog at UFC 270, now that only 35% of the money has been wagered on the champ.

Ngannou knocked out Stipe Miocic on March 27, 2021, for the title. The champ has won five straight fights by knockout, but he’s yet to defend his belt. Gane is a perfect 10-0 in his professional MMA career. A third-round TKO of Derrick Lewis in August at UFC 265 made hin the interim champion.

There will need to be an upset in order for a new UFC flyweight champion to be crowned Saturday. Seven months after winning the 115-pound title, Brandon Moreno has -175 odds to retain against Deiveson Figueiredo. Figueiredo is a +145 underdog.

While Figueiredo has received 57% of the bets, 73% of the money has been wagered on Moreno to win.

The welterweight fight between Michel Pereira and André Fialho is viewed as the most one-sided of the UFC 270 card. Pereira opened as a -300 favorite and his odds have remained unchanged, despite only receiving 24% of the bets and 13% of the handle.

Rodolfo Vieira (-250) and Said Nurmagomedov (-200) are also favored to win fights on the main card.

UFC 270 starts at 10 p.m. EST Saturday from the Honda Center.

Francis Ngannou
JACKSONVILLE, FLORIDA - MAY 09: Francis Ngannou (R) of Cameroon misses a punch against Jair Rozenstruik of Suriname in their Heavyweight fight during UFC 249 at VyStar Veterans Memorial Arena on May 09, 2020 in Jacksonville, Florida. (Photo by Douglas P. DeFelice/Getty Images)