The match starts at 4 p.m. eastern time, or 9 p.m. London time. The men's final is usually played on Sunday, but due to the weather problems on the east coast, the match had to be postponed until Monday.
Both players dropped the first set of the semi-final match, before winning the next three.
The final marks Murray's second appearance in the U.S. Open final, as the Scot pursues his first Grand Slam title.
Djokovic is a five-time Grand Slam winner, and the Serbian star has a 27-match winning streak in hardcourt grand slams.
The final should be entertaining as Djokovic has just an 8-6 head-to-head edge over Murray, but Murray won the most recent meeting at the London Olympics. Both players are 25 years old, and both are looking to seize off the tournament absence of Rafael Nadal and the early elimination of Roger Federer.
Murray may have the momentum following his gold-medal effort this summer.
"Murray is believing he's a winner," said famed youth tennis coach Nick Bollettieri, according to BBC.com. "He didn't believe it before. He would be emotional, break his focus. But, right now, watch his focus. Shoulders up square like a paratrooper, he looks like a warrior."