When and where: The Premier League match kicks-off from Stamford Bridge at 2.45 p.m. ET. Coverage will be provided by ESPN2, with a live stream available on ESPN3.
Preview: Chelsea will be overwhelming favorites to make it two wins from as many games as they take on Reading at Stamford Bridge. The Blues got their Premier League season off to a winning start on Sunday as they overcame a Wigan side 2-0, with both strikes coming in the opening 10 minutes.
Eden Hazard stole the show as he played a key role in both strikes and coach Roberto Di Matteo will hope for more of the same on the Belgian's home debut.
While the result looked comfortable, the Italian will be aware that there is still plenty of work to do in order to translate a massive summer of spending into a successful season on the pitch. Despite claiming a first ever Champions League last season, there was more than a sense that the triumph represented a last hurrah for a particular generation and style of play that was established under Jose Mourinho.
Having signed three creative midfielders in Hazard, Oscar and Marko Marin, there is clearly an intention to shift toward a more possession-based, short-passing game, something that will take time to implement. Yet, as is always the case at Stamford Bridge, Di Matteo will be under pressure should good results not be maintained through the transition.
Di Matteo will still be without Marin for Wednesday's match while David Luiz has been sidelined with a knee injury. There is some good news, though, in the likely return from illness of fellow-Brazilian Ramires.
Behind for much of their opening encounter, Reading celebrated their return to the Premier League with a credible draw at home to Stoke. A late penalty from Adam Le Fondre means that Brian McDermott's side can go into the match against Chelsea with some momentum. While a trip to Stamford Bridge poses a daunting challenge for any side, the Reading players should relish the occasion having strived to achieve promotion from the Championship last season.
McDermott will be hoping that his major summer acquisition Pavel Pogrebnyak can begin scoring the goals to repay the faith shown in him by the offer of a lucrative four-year contract. The Russia international struck six goals in 12 appearances while on loan at Fulham from Stuttgart during the second half of last season.
Fellow striker Jason Roberts will be missing against Chelsea due to suspension, while Jimmy Kebe and Jem Karacan are out with injuries.
D: Ivanovic, Cahill, Terry, Cole
M: Mikel, Lampard
Mata, Oscar, Hazard
D: Gunter, Pearce, Gorkss, Harte
M: McAnuff, Guthrie, Leigertwood, Robson-Kanu
F: Pogrebnyak, Le Fondre
Prediction: Despite their additions, there could well be plenty of teething problems with the new-look Chelsea. At home to Reading, there vulnerabilities, are likely to be exposed, however. After a cameo appearance against Wigan, silky Brazilian Oscar may make his first start to complete a stunning attacking midfield tandem alongside Eden Hazard and Juan Mata.
Chelsea 2-1 Reading