Number 11-seed Marquette battled with number three-seed Syracuse in Cleveland, and hit big shots at the end to beat the Orange, 66-62.
The Golden Eagles are on their way to the Sweet 16.
It was a tight game for 25 of the 40 minutes. Syracuse led by 10 points early on, before Marquette mounted a comeback, and kept the game close in the second half.
Marquette was led by guard Darius Johnson-Odom, who scored 17 points, but it was his three-point shot with 27 second remaining and the game tied, that helped win Marquette the game.
Syracuse was led by freshman Dion Waiters, who had a big second half, and finished with 18 points on eight-of-10 shooting.
The Orange shot 55.3 percent from the field in the loss, but only took seven free-throw attempts.
Meanwhile, Marquette shot 19-of-23 from the free-throw line. The Golden Eagles were also five-of-11 from beyond the three-point arc.
Marquette will play North Carolina in Newark, New Jersey.