Khloe Kardashian is reaching out to her younger brother Rob, after he has distanced himself from his famous family. The 29-year-old, who often defends and supports Rob via social media, posted a picture of the two from their younger days, along with the caption, “I miss my best friend.”

Rob reportedly is over the reality show that put his family in the spotlight: E!’s “Keeping Up With the Kardashians.” The 27-year-old, who has been famously struggling with his weight over the past year, has retreated into anonymity, and does not want to have a recurring storyline on the popular television program.

The younger brother “has been holed up in his house and hasn’t been returning calls from concerned family members. Rob made the decision months ago that he didn’t want to have a recurring storyline on the upcoming season of 'KUWTK' and drastically cut back on filming,” a source told RadarOnline.

He has already begun avoiding his family members. Last month, he ditched his sister Kim’s wedding in Italy and flew back home to Los Angeles. "He wanted to be there, but he was feeling so insecure and didn't want anyone to see him heavier like this. Kim and Kanye completely understand. They love Rob and only want him to be healthy and happy," a source told E!

Apparently, he feels the reality show has “ruined his family,” and the weight gain has not helped. Sister Khloe has come to Rob’s defense recently, after he began trending on Twitter due to his weight.

“I love you @robkardashian,” the 29-year-old tweeted. “Some of you people are disgusting for calling others names and picking on them. You should be ashamed of your self [sic]. Your workds are cutting deeper than you know and are possible leaving lifetime scars [sic],” she said, adding, “What shallow souls some of you are. Its sickening to critique anyone off of their appearance. Grow up!”

Rob is not the only Kardashian who has been blasted in the media because of their size. For years, Khloe also faced backlash for years due to her stature and weight. The 5-foot-10-inch reality star has since lost at least 30 pounds by working out and eating healthier food.