It's the first Clasico in 2012.
Perhaps the two best clubs in the world meet at Santiago Bernabeu as Real Madrid host Barcelona in the first leg of the quarter-finals of Copa Del Rey on Wednesday.
The last time Real Madrid defeated Barcelona it was in the Copa Del Rey Final, but Barcelona defeated Real Madrid in December on Los Galacticos' home turf.
The match pits perhaps the two best players in the world against one another: Lionel Messi and Cristiano Ronaldo.
Here is the starting lineup for the match:
Real Madrid Starting XI:
D: Diarra, Pepe, Ramos, Marcelo
M: Alonso, Coentrao, Callejon, Ozil, Ronaldo
Subs: Carvalho, Sahin, Kaka, Granero, Adan, Hamit Altintop, Albiol, Varane, Higuain, Di Maria, Mejias
Barcelona Starting XI:
D: Alves, Pique, Puyol, Abidal
M: Iniesta, Busquets, Xavi
F: Fabregas, Messi, Sanchez
Subs: Valdes, Thiago, Mascherano, Adriano, Jonathan dos Santos, Sergi Roberto, Cuenca