Ann Coulter arrives at the Time 100 Gala in New York, April 24, 2012. The Time 100 is an annual list of the 100 most influential people in the last year complied by Time magazine. Reuters

Conservative pundit Ann Coulter is not known for her good manners, but she seemingly crossed a new barrier of hostility Wednesday night when she tweeted offensive comments about Jewish Americans as the GOP candidates debated Israel and national security. Coulter, who seemed to be accusing the candidates of pandering to Jewish voters after four of 11 candidates mentioned their support for Israel in their closing remarks, questioned the number of Jewish people the candidates thought lived in the United States.

Coulter, who has 660,000 Twitter followers, was following the second televised Republican debate held Wednesday at the Ronald Reagan Library in California. She also wrote of former Arkansas Gov. Mike Huckabee: "Good Grief, Huckabee is running for prime minister of Israel." Coulter continued her Twitter rant by noting: "How to get applause from GOP donors: 1) Pledge to start a war 2) Talk about job creators 3) Denounce abortion 4) Cite Reagan 5) Cite Israel." Meanwhile, Coulter referenced the Holocaust in her review of the debate Wednesday, writing, "The other problem with the Be Reagan strategy is: It's not 1980 anymore. Reagan's election is as far away today as the defeat of Hitler was then."

Coulter has insulted Jewish Americans before. In a 2007 interview on CNBC's "The Big Idea," Coulter told Jewish host Donny Deutsch that she wants her dream America to be completely Christian.

Roughly 7 million Jews live in the United States. The four candidates who mentioned Israel during the debate hosted by CNN were Huckabee, Sen. Ted Cruz, R-Texas, Sen. Marco Rubio of Florida and New Jersey Gov. Chris Christie.

After Coulter's tweet, some social media users said her account had been hacked, while others slammed her remarks. Followers called Coulter "anti-Semitic," and "desperate for attention," calling her statement "f---ing offensive." Others defended her, as #IStandWithAnn began trending on Twitter Thursday morning.