Clemson quarterback Trevor Lawrence has tested positive for the coronavirus, raising questions over when college football’s biggest star can return to the field. The Tigers’ star will miss Saturday’s game against Boston College, and his status for Clemson’s following game against Notre Dame is also in doubt.

Lawrence said in a statement that he’s experiencing relatively mild symptoms. ACC protocols stipulate that a player who has a positive coronavirus test must isolate for 10 days once they start experiencing symptoms. Lawrence took the test Wednesday, though it’s unknown exactly when his symptoms began.

Before he can return, Lawrence must have no symptoms or fever for 24 hours. He has to undergo cardiac testing and be cleared to play by team doctors.

A matchup with No. 4 Notre Dame is next on top-ranked Clemson’s schedule after Saturday’s meeting with Boston College. The Nov. 7 game in South Bend, Indiana would mark exactly 10 days since Lawrence took his coronavirus test.

If Lawrence is able to play against Notre Dame, he’ll have to do so without any practice time in the previous 10 days.

Freshman quarterback D.J. Uiagalelei will replace Lawrence on Saturday. Even without their starter, the Tigers are expected to handle the Eagles. Clemson is a 24-point favorite at home, according to odds compiled by OddsShark.

Beating Notre Dame, a national championship contender, would be much more difficult if Lawrence can’t suit up. Along with the Tigers, the Fighting Irish are the only other ACC team with a perfect record. Notre Dame has outscored its four ACC opponents by 77 points.

Clemson is favored to win the national title.

Clemson doesn’t play for another two weeks after visiting Notre Dame. The Tigers are scheduled to take on Florida State on Nov. 21. Clemson hosts Pittsburgh on Nov. 28.

Lawrence is projected to be the top pick in the 2021 NFL Draft. He’s also favored to win the Heisman Trophy following consecutive trips to the National Championship Game in each of his first two seasons.

Clemson football Trevor Lawrence Clemson quarterback Trevor Lawrence addresses the media before the "March for Change" protest at Bowman Field on June 13, 2020 in Clemson, South Carolina. Photo: Maddie Meyer/Getty Images