The Big Ten finally returns in Week 8 of the 2020 college football season, with five teams ranked in the AP Top 25 Poll. Each team in the conference is set to play an eight-game schedule, leaving no margin for error in the chase for a national championship.

No. 5 Ohio State is a 26-point favorite in its debut against Nebraska. No. 14 Wisconsin is expected to win going away Friday night, laying nearly 20 points against Illinois.

A few of the Big Ten’s top teams could have their hands full in their openers. No. 8 Penn State is favored by less than a touchdown in a trip to Indiana. No. 18 Michigan is favored by a field goal on the road against No. 21 Minnesota.

No. 1 Clemson is the biggest favorite on the entire schedule, laying 46 points against visiting Syracuse. Trevor Lawrence threw for 391 yards and five touchdown passes in the first half of the Tigers’ 73-7 victory over Georgia Tech last week.

No. 2 Alabama and No.20 Kansas State are both favored by three touchdowns. No. 12 BYU is a four-touchdown favorite.

No. 17 Iowa State visits No. 6 Oklahoma State in arguably the best matchup on the schedule. The point spread is just north of a field goal.

Here are the betting lines for all the Week 8 college football games with top-25 teams, including the point spreads and totals. These are the consensus odds from multiple online sportsbooks, via OddsShark.

Illinois (+19.5) at No. 14 Wisconsin, 51.5

Nebraska (+26) at No. 5 Ohio State, 68

Syracuse (+46) at No. 1 Clemson, 62

No.23 NC State (+15) at No. 14 North Carolina, 60

Kansas (+20) at No. 20 Kansas State, 48.5

Georgia Southern (+5.5) at No. 25 Coastal Carolina, 51.5

Florida Atlantic (+17) at No. 22 Marshall, 51

No. 2 Alabama (-21.5) at Tennessee, 66

No. 3 Notre Dame (-10) at Pittsburgh, 42.5

No. 17 Iowa State (+3.5) at No. 6 Oklahoma State, 52

No. 8 Penn State (-5.5) at Indiana, 62

No. 19 Virginia Tech (-9.5) at Wake Forest, 68

No. 18 Michigan (-3) at No. 21 Minnesota, 54

Virginia (+12.5) at No. 11 Miami, 57.5

No. 9 Cincinnati (+2.5) at No. 16 SMU, 55.5

Texas State (+28.5) at No. 12 BYU, 60.5

Justin Fields Ohio State
Quarterback Justin Fields #1 of the Ohio State Buckeyes scrambles with the football during the PlayStation Fiesta Bowl against the Clemson Tigers at State Farm Stadium on December 28, 2019 in Glendale, Arizona. Christian Petersen/Getty Images