For the first time in the 2021 NFL season, games will be played on a Tuesday. The matchup between the Washington Football Team and Philadelphia Eagles was moved from Sunday because of COVID-19 cases, as well as the contest between the Los Angeles Rams and Seattle Seahawks.

Both games are set to start at 7 p.m. EST on Fox. The betting odds have seen massive swings with players going on and off the COVID-19/reserve list.

Here are the predictions against the spread for the Tuesday schedule. Betting lines come from DraftKings Sportsbook.

Washington Football Team (+6.5) at Philadelphia Eagles, 42.5

Washington greatly benefited from this game being moved from Sunday. The team had 23 players sidelined because of COVID-19, and several key contributors will now be available in this important NFC East matchup. Four defensive linemen, including Jonathan Allen and Montez Sweat, are back on the active roster. There’s a real chance that either Taylor Heinicke or Kyle Allen will be able to come off the COVID list and start at quarterback.

Both teams are 6-7 and outside of the latest playoff picture. If one of its top two signal-callers is under center, Washington should remain competitive. Washington’s four-game winning streak was snapped with a 27-20 loss against the Dallas Cowboys last week. The team was last defeated by more than a touchdown in Week 8.

Prediction: Philadelphia over Washington, 20-17

Seattle Seahawks (+7) at Los Angeles Rams, 46

The Rams had as many as 25 players on the COVID list before a bunch of players were placed back on the active roster. Wide receiver Odell Beckham was one of six players activated Saturday, and cornerback Jalen Ramsey can play after missing Los Angeles’ Week 14 win over the Arizona Cardinals. As of Monday afternoon, receiver Tyler Lockett, starting cornerback D.J. Reed, and starting right tackle Brandon Shell are among Seahawks on the COVID list.

This point spread has moved around all week. The line dropped from 6.5 points to 3.5 points Friday, and it’s up to a touchdown with Los Angeles getting key players back. As long as Russell Wilson is on the field for Seattle, the Seahawks have a chance to pull off the upset. Seattle hasn’t given up more than 23 points in 10 weeks.

Prediction: Los Angeles over Seattle, 23-20

Matthew Stafford Los Angeles Rams
Quarterback Matthew Stafford #9 of the Los Angeles Rams celebrates with running back Darrell Henderson #27 after scoring a touchdown against the Seattle Seahawks in the second half at Lumen Field on Oct. 7, 2021, in Seattle. Lindsey Wasson/Getty Images