With one week of the 2020 NFL season in the books, favorites are 8-7-1 against the spread and 6-10 straight up. Home teams went 9-6-1 against the spread, including a 2-0 record for teams that had fans in the stands. 

Here are picks against the spread for every game in Week 2, as well as the latest betting odds. Betting lines and trends are courtesy of OddsShark.

Cincinnati Bengals (+6) at Cleveland Browns

Betting on Cleveland as a significant favorite doesn’t seem like the wisest decision, given their repeated history of embarrassing performances. If Joe Burrow leads the Bengals past the Browns Thursday night, it’s going to raise even more questions about the future of Baker Mayfield and this team.

Prediction ATS: Cincinnati

Detroit Lions (+6) at Green Bay Packers

Detroit nearly beat Green Bay twice last year, and they are 6-0 against the spread in their last six games against the Packers. The Lions were cruising to a Week 1 win before allowing 21 unanswered points in the fourth quarter. Detroit’s secondary will perform better than Minnesota’s defensive backs, whom Aaron Rodgers torched in the opener.

Prediction ATS: Detroit

New York Giants (+5.5) at Chicago Bears

Give credit to Mitchell Trubisky for engineering a fourth-quarter comeback in Week 1, but don’t forget about his first three quarters either. Allen Robinson’s reported frustration with the Bears doesn’t help matters. Maybe Daniel Jones can limit his costly turnovers and help the Giants pull off an upset.

Prediction ATS: New York

Jacksonville Jaguars (+9) at Tennessee Titans 

Gardner Minshew could make it difficult for Jacksonville to tank for the No.1 overall draft pick. The second-year player led all quarterbacks by completing 95% of his passes last week in a win over Indianapolis. Tennessee’s kicking woes could prevent the Titans from winning comfortably.

Prediction ATS: Jacksonville

 

 

Atlanta Falcons (+4.5) at Dallas Cowboys

This should be a fun game between two high-powered offenses that can put up points in a hurry. Look for Dak Prescott to be more aggressive than he was in Week 1. Matt Ryan leads the league with 450 passing yards and could exploit a Dallas defense that’s dealing with some key injuries. A late field goal could decide the outcome.

Prediction ATS: Atlanta 

San Francisco 49ers (-7) at New York Jets

Without a ton of weapons, Sam Darnold struggled mightily in the opener against Buffalo’s defense. Now that Le’Veon Bell is out, the quarterback probably won’t perform much better when the Jets host the top passing defense from a season ago. New York is 1-6 against the spread in their last seven September games.

Prediction ATS: San Francisco

Los Angeles Rams (-1) at Philadelphia Eagles

Carson Wentz was the NFL’s worst quarterback in Week 1, and he’s too good to have a similar performance Sunday. Right tackle Lane Johnson is expected to make his season debut in Week 2. Since 2016, the Eagles are 36-17 when Johnson plays and 6-12 without him.

Prediction ATS: Philadelphia

Carolina Panthers (+9) at Tampa Bay Buccaneers

Tom Brady and the Tampa Bay offense don’t appear to be in sync just yet. Carolina’s offense looked good under new head coach Matt Rhule and offensive coordinator Joe Brady with 30 points in Week 1. This could be one of the most exciting games on the Week 2 schedule

Prediction ATS: Carolina

Denver Broncos (+7.5) at Pittsburgh Steelers

Drew Lock has plenty of growing pains ahead of him following a shaky Week 1 performance. Denver’s defense benefited from three missed Tennessee field goals. Potentially losing cornerback A.J. Bouye for a few weeks is significant. Ben Roethlisberger appears to be at least close to his old form, which is big news for a team that has a defense as good as Pittsburgh’s.

Prediction ATS: Pittsburgh

Minnesota Vikings (+3) at Indianapolis Colts

In his Colts debut, Philip Rivers made similar mistakes to the ones that plagued him last year, throwing two interceptions and another pick that was erased by a penalty. With their home stadium capped at 2,500 fans, Indianapolis shouldn’t be favored by a field goal over Minnesota.

Prediction ATS: Minnesota

Buffalo Bills (-6) at Miami Dolphins

After having trouble against Cam Newton in Week 1, the Dolphins won’t fare any better against Josh Allen in Week 2. Allen posted a passer rating north of 111.0 in both of Buffalo’s double-digit wins over Miami last year. Ryan Fitzpatrick is going to struggle against one of the AFC’s top defenses.

Prediction ATS: Buffalo

Washington Redskins (+7) at Arizona Cardinals

Arizona probably needs to show more before being favored by a touchdown. For all their faults, Washington could have a dangerous pass rush this season that keeps them in a lot of games. The Redskins led the NFL with 15 quarterback hits in the opening week.

Prediction ATS: Washington

 

 

Kansas City Chiefs (-8.5) at Los Angeles Chargers 

Kansas City is 17-3 against the spread in their last 20 AFC West matchups on the road. The Chiefs are 6-1 ATS in their last six matchups with the Chargers. The quarterback disparity is greater than it was in any of those games now that Tyrod Taylor has replaced Rivers and Patrick Mahomes is the NFL’s best player.

Prediction ATS: Kansas City

Baltimore Ravens (-7) at Houston Texans

It’s hard to bet against the Ravens when they are only laying single digits. Lamar Jackson and Baltimore picked up where they left off last year, defeating Cleveland by 32 points in Week 1. The Ravens finished the 2019 season with nine wins by at least seven points in their last 10 games. That included a 41-7 victory over Houston.

Prediction ATS: Baltimore

New England Patriots (+4) at Seattle Seahawks

Russell Wilson posted a 143.1 passer rating in the opener, potentially kicking off an MVP season. The Seahawks should have one of the NFC’s top offenses, while a lack of playmakers could cause the Patriots to struggle to move the ball for a second straight year. Seattle has scored at least 24 points in all three games against New England with Russell Wilson under center. 

Prediction ATS: Seattle

New Orleans Saints (-5.5) at Las Vegas Raiders

The Saints might be the play here with the point spread dipping well below a touchdown. Drew Brees could carve up a defense that just allowed Teddy Bridgewater and the Panthers to score 30 points.

Prediction ATS: New Orleans

Season Record: 7-8-1

Russell Wilson Seattle Seahawks Russell Wilson #3 of the Seattle Seahawks celebrates with Chris Carson #32 after a touchdown against the Atlanta Falcons at Mercedes-Benz Stadium on September 13, 2020 in Atlanta, Georgia. Photo: Kevin C. Cox/Getty Images