Hector "Macho" Camacho, a three-time boxing champion and flamboyant fighter, died Saturday morning in San Juan, Puerto Rico, after being taken off life support at his family's request.

Doctors at Centro Medico Trauma Center had declared the 50-year-old brain dead on Thursday. Camacho, who was shot in the face and neck on Tuesday, had suffered a second heart attack on Saturday morning.

A public wake for the boxer at the Department of Sports & Recreation headquarters in San Juan is reportedly in the works. Camacho has four children from different relationships, and a son who is also a boxer.

There have been no arrests on the two gunmen involved in the Tuesday shooting in a parking lot in Bayamon, a suburb of San Juan and the birthplace of Camacho. Also in the parked car was Adrian Mojica Moreno, Camacho's childhood friend, who was shot and killed at the scene. Ten bags of cocaine were found in the car.

Camacho enjoyed a prolific career as a super featherweight and lightweight. The southpaw famously fought Sugar Ray Leonard, Roberto Duran, Julio Cesar Chavez, Felix Trinidad and Oscar De La Hoya. Camacho compiled a 79-6-3 with 38 knockouts.

Camacho also dealt with problems outside the ring. He was sentenced to seven years in prison for burglary in Mississippi and also battled alcohol and drug problems during his career.