The Philadelphia Eagles, one of the NFC favorites to go to the Super Bowl, were delivered a double blow on Sunday with the loss of Michael Vick to injury, and a home loss the division rival New York Giants, 29-16.

Vick, who suffered a concussion last week in his much-anticipated return to Atlanta, helped the Eagles come back from a 14-0 deficit to take the lead, 16-14, but left in the fourth quarter with a broken hand.

The injury took place on what looked like a late hit by by defensive tackle Chris Canty, as Vick completed a 23-yard pass to wide receiver Jeremy Maclin.

With Vick sidelined, Giants quarterback Eli Manning shined, as New York improved their record to 2-1. Manning completed 16-of-23 passes for 254, and also threw for four touchdowns without throwing an interception.

Manning's main target was Victor Cruz, a second-year player out of the University of Massachusetts, who gained 110 yards off three receptions, two of which were touchdown catches.

The Eagles were undone by turnovers. The defense failed to force the Giants into giving up the ball, while Vick and backup quarterback Mike Kafka combined for three interceptions.

Both of the fourth-quarter drives that Kafka led, ended in interceptions, including his first pass of the game. The Eagles led going into the fourth quarter, 16-14, before conceding 15-straight points.

The Eagles received a great effort from LeSean McCoy. The third-year running back rushed for 128 yards on 24 carries, including an 11-yard touchdown run in the second quarter.

It's always good to beat those guys, especially here, said Manning. They have good players and we knew we had to come in with the same game plan as last year and just finish it this time. 

The Giants travel to Phoenix to play the Cardinals next Sunday, while the Eagles host the 49ers.

Here are the highlights from the Giants - Eagles game in Week Three.