The odds are against the Tennessee Titans for when they finally return to the field Tuesday night to host the Buffalo Bills.

Tennessee is a 3.5-point home underdog against Buffalo in Week 5, according to betting lines compiled by OddsShark. The point spread might have favored the Titans if it weren’t for a coronavirus outbreak within the organization that has altered the team’s schedule.

A rash of positive coronavirus tests shut down the Titans’ facility on Sept. 29, two days after they defeated the Minnesota Vikings for a 3-0 record. Tennessee’s Oct. 4 matchup with the Pittsburgh Steelers was postponed, and the Titans were cleared to practice together Saturday, Oct. 10.

That gives Tennessee only a few days to prepare in-person for another one of the NFL’s teams that still has a perfect record.

Buffalo improved to 4-0 in Week 4. The Bills handily beat the Las Vegas Raiders, a win that seems even more impressive after the Raiders upset the Kansas Chiefs Sunday at Arrowhead Stadium.

Josh Allen has been spectacular, inserting himself into the very early MVP conversation. The third-year quarterback has completed 70.9% of his passes for 1,326 yards, 12 touchdowns, one interception and a 122.7 passer rating. Allen has added 83 yards and three scores on the ground.

The Bills are fourth in the NFL in yards per play. Buffalo beat the New York Jets 27-17 in Week 1 and has scored at least 30 points in every game since the opener.

The Titans have surpassed the 30-point mark in both of their games since escaping with a 16-14 victory over the Denver Broncos in the opener. Tennessee outlasted the Jacksonville Jaguars 33-30 in Week 2. A late field goal pushed the Titans past the Vikings 31-30 in Week 3.

Ryan Tannehill had his first subpar performance of the 2020 season in Minnesota when he threw for no touchdowns, one interception and a 78.8 passer rating. The quarterback has a 105.8 passer rating, following his league-leading 117.5 passer rating in 2019. Tannehill isn’t among the handful of players who are set to miss Tuesday’s game with the coronavirus.

Receiver A.J. Brown could play for the first time since Week 1. Derrick Henry is averaging 106 rushing yards per game.

Buffalo is 21st in opponents’ yards per play. Despite the long layoff, Tennessee’s offense could move the ball effectively Tuesday.

The Titans’ defense has had an uneven start to the year. The lack of practice time might hurt the unit as it plays a game for the first time in 16 days. Week 5 could end with yet another high-scoring affair.

The over/under is 53.5.

The Bills have also been forced to deal with plenty of uncertainty. It’s been unknown if Buffalo would return to the field Tuesday or Thursday night for a game against the Kansas City Chiefs.

Don’t be surprised if the Titans win an exciting game to stay perfect on the season.

Prediction: Tennessee over Buffalo, 30-27

Tennessee Titans
The Tennessee Titans and take the field before the game against the Minnesota Vikings at U.S. Bank Stadium on September 27, 2020 in Minneapolis, Minnesota. Stephen Maturen/Getty Images)