NBC’s “Chicago Med” is upping the drama a notch in Season 2. The Season 1 finale showed Dr. Connor Rhodes bidding adieu to his mentor Dr. Downey after he succumbed to cancer. Meanwhile, April’s boyfriend proposed to her but the romance was thwarted by the former’s tuberculosis diagnosis. What will happen in the Season 2 premiere of the medical drama?

Episode 1 kicks off with Dr. Rhodes (Colin Donnell) commencing his fellowship in cardiothoracic surgery with a new and more challenging mentor, Dr. Latham (Ato Essandoh), according to the synopsis (via SpoilerTV). However, he gets off on the wrong foot.

Meanwhile, Dr. Ethan Choi (Brian Tee) gets promoted to Chief Resident but he quickly finds out that handling his new position is more difficult that he thought.

On the other hand, nurse April (Yaya DaCosta) tries to come to term with her TB diagnosis. Will she eventually tell her boyfriend about the illness?

The Season 2 premiere of “Chicago Med” will also show Dr. Manning (Torrey DeVitto) take on a complicated case. She will treat a pregnant woman who was also a victim of a high speed collision.

Interestingly, the season premiere will also show Dr. Charles (Oliver Platt) approach Sarah (Rachel DiPillo) with an interesting opportunity that catches her off-guard.

“Soul Care” will also see Dr. Halstead (Nick Gehlfuss) take exception to the actions of Jeff Clarke (Jeff Hephner), a fourth-year medical student who was introduced in the Season 1 finale. His past history with Dr. Manning may be the reason why the doctor took offense to Clarke’s actions.

Elsewhere, Sharon Goodwin (S. Epatha Merkerson), whose husband left her in the season finale, will try to move on with her life.

“Chicago Med” Season 2 premieres on Thursday, Sept. 22, at 9 p.m. EDT on NBC.