NBC’s “Chicago Med” is upping the drama a notch with the introduction of new characters and spicing up some of the existing characters’ storylines. The Season 1 finale ended with Dr. Connor Rhodes losing his mentor, Dr. David Downey, after cancer took hold of him. Also, in a shocking twist, nurse April Sexton’s medical exam revealed that she has tuberculosis.

What will happen to Rhodes (Colin Donnell), April (Yaya DaCosta) and other “Chicago Med” characters in Season 2? Here are five things to know about the upcoming season on the medical drama series:

1. Rhodes Will Get A New Mentor

Rhodes’ new mentor, Dr. Latham, is a challenging personality, TVGuide reports. He makes the good doctor wonder whether he made the right career choice. Whether he will be able to work with Dr. Latham for two years in order to complete his fellowship remains to be seen in “Chicago Med” Season 2.

However, career isn’t the only thing on Rhodes’ mind in the upcoming season of the NBC series. He will also be romantically linked to someone who has an unexpected connection to the Gaffney Chicago Medical Center.

2. April’s Relationship With Her Boyfriend Gets A Little Tensed

As expected, April’s disease causes some tension in her relationship. The emotional impact from learning that she has TB will cause some friction between her and her boyfriend.

3. Sarah Reese (Rachel DiPillo) Returns

Despite turning down the offer to work in pathology after graduation, Reese will be back at the hospital as a resident.

4. Choi (Brian Tee) Gets A Promotion

Dr. Ethan Choi will be the chief resident of the hospital.

5. Goodwin (S. Epatha Merkerson) is single

After her husband left her in Season 1, Sharon Goodwin is single and looking for love.

Watch “Chicago Med” Season 2, episode 1 on Thursday, Sept. 22 at 9 p.m. EDT on NBC.