NFL point spreads are constantly changing amid the increased number of COVID-19 cases around the league. Seven of the 16 games in Week 16 feature a betting line of three points or fewer. There are three double-digit favorites on the upcoming schedule.

Here are picks against the spread for every game in Week 16 of the 2021 season, as well as updated betting odds. Betting lines come from FanDuel Sportsbook.

San Francisco 49ers (-3.5) at Tennessee Titans

The Titans are probably the right pick as underdogs of more than a field goal. Tennessee’s defense is still underrated and ranks ahead of San Francisco in opponents’ yards per play. Jimmy Garoppolo might be due for a lackluster performance after a string of strong games.

Prediction ATS: Tennessee

Cleveland Browns (+8) at Green Bay Packers

There is still a ton of uncertainty regarding how many key Cleveland players will be on the COVID-19 reserve list at game time. Green Bay can at least be assured that Aaron Rodgers and Davante Adams will be available, since they already missed games with COVID within the last two months. Green Bay is 11-1 in Rodgers’ last 12 starts.

Prediction ATS: Green Bay

Indianapolis Colts (+1) at Arizona Cardinals

The Cardinals are still one of the NFC’s best teams, despite losing two games in a row and DeAndre Hopkins for the rest of the regular season. Carson Wentz only threw for 57 yards in Indianapolis’ Week 15 victory over New England. That won’t be a winning formula in Arizona. The Cardinals held Derrick Henry to 58 yards in Week 1, a possible sign that they are ready to slow down Jonathan Taylor.

Prediction ATS: Arizona

Tampa Bay Buccaneers (-11) at Carolina Panthers

Tampa Bay was shut out in Week 15 as Chris Godwin, Mike Evans and Leonard Fournette all went down with injuries. Godwin won’t play in Carolina, and Evans could be out as well. If Sam Darnold is back under center, he can give the Panthers a chance to be competitive or at least have a backdoor cover.

Prediction ATS: Carolina

Los Angeles Chargers (-9.5) at Houston Texans

As a single-digit favorite, the Chargers are the best bet here. The Texans have been a disaster when they don’t face the Jaguars, being outscored by an average score of 28-12 in 12 games. Los Angeles is averaging 32 points in the last five games.

Prediction ATS: Los Angeles

New York Giants (+10) at Philadelphia Eagles

With Daniel Jones out, the Giants might have the NFL’s worst quarterback situation with Mike Glennon and Jake Fromm as their top options. Philadelphia can rush the passer as well as anyone, and New York’s offensive line ranks near the bottom of the league. New York has scored 13 points or fewer in four of the last five games.

Prediction ATS: Philadelphia

Baltimore Ravens (+2.5) at Cincinnati Bengals

Baltimore is on a three-game losing streak, but those losses have come by a total of five points. Since their Week 8 bye, the Ravens have only been defeated by three points or more once. The Bengals' 41-17 win over the Ravens in Week 7 was closer than the final score indicates.

Prediction ATS: Baltimore

Detroit Lions (+6) at Atlanta Falcons

With a 2-3-1 record over their last six games, the Lions have been a better team than the Falcons since Week 10. Two of those losses came by a total of five points. Atlanta gives up an NFC-worst 27.4 points per game.

Prediction ATS: Detroit

Jacksonville Jaguars (+2.5) at New York Jets

With or without Urban Meyer as head coach, the Jaguars are the worst team in the NFL. Jacksonville hasn't won a road game in two years. Trevor Lawrence has one touchdown pass and five interceptions in his last seven games.

Prediction ATS: New York

Los Angeles Rams (-3) at Minnesota Vikings

Minnesota leads the league in sacks, but it could have trouble getting much pressure against Matthew Stafford and an L.A. offensive line that leads the NFC in ESPN’s team pass block win rate. Aaron Donald, on the other hand, can make life miserable for Kirk Cousins. The Rams are 6-0 against teams that don’t have a record above .500.

Prediction ATS: Los Angeles

Buffalo Bills (+1.5) at New England Patriots

A few weeks after New England beat Buffalo 14-10, this game is essentially a toss-up. The Bills should have a better chance to win the second meeting if weather conditions are improved and Mac Jones has to attempt more than three passes.

Prediction ATS: Buffalo

Chicago Bears (+7) at Seattle Seahawks

The Bears have lost eight of their last nine games, including six defeats by double digits. Among NFC teams, Chicago ranks in the bottom-three in both scoring offense and defense. Since September ended, the Rams are the only team to score more than 23 points against the Seahawks.

Prediction ATS: Seattle

Denver Broncos (+1.5) at Las Vegas Raiders

The Raiders needed a last-second field goal to beat a Browns team that was missing several starters and down to its third-string quarterback. Derek Carr had a 134.4 passer rating in Las Vegas’ 34-24 win over Denver in Week 6. Don’t expect a repeat performance for Carr against an elite Broncos secondary.

Prediction ATS: Denver

Pittsburgh Steelers (+9.5) at Kansas City Chiefs

This line is probably too high, given the many close Steelers games. Only the Bengals and Packers have beaten the Steelers by more than nine points.

Prediction ATS: Pittsburgh

Washington Football Team (+10) at Dallas Cowboys

Dallas beat Washington 27-20 two weeks ago, and Sunday night’s matchup could be a similar contest. With Dak Prescott posting an average passer rating of 86.1 in his last seven starts, the Cowboys only have two wins by more than 10 points during that stretch.

Prediction ATS: Washington

Miami Dolphins (+3) at New Orleans Saints

Miami’s defense hasn’t surrendered more than 17 offensive points in any game during its six-game winning streak. The Dolphins prevented Lamar Jackson and Cam Newton from having much success on the ground in two of those victories. Taysom Hill is averaging 197.7 passing yards with two passing touchdowns and four interceptions in three games as the Saints’ starting quarterback.

Prediction ATS: Miami

Season Record: 107-114-3

Tua Tagovailoa Miami Dolphins
Tua Tagovailoa #1 of the Miami Dolphins throws the ball at the Baptist Health Training Complex on August 25, 2021 in Miami Gardens, Florida. Joel Auerbach/Getty Images