Betting on the final week of the NFL regular season can be challenging because of the uncertainty surrounding teams that have very little on the line. A pair of division champions are underdogs Sunday afternoon. Five teams are favored by at least a touchdown.

Here are picks against the spread for every game in Week 17 of the NFL season, as well as the latest odds.

Betting lines and trends are courtesy of OddsShark.

New York Jets (+3) at New England Patriots

Bill Belichick hasn’t said if Cam Newton or Jarrett Stidham will get the start Sunday. Either way, the Jets might have the better quarterback in this game. New York is a Hail Mary away from three wins in December, while the Patriots look like a team that can’t wait for the season to end.

Prediction ATS: New York

Minnesota Vikings (-7) at Detroit Lions

Kirk Cousins and the Vikings punish bad defenses, and the Lions have the league’s worst defense at this stage of the season. Detroit has given up an average of 39 points in its last five games.

Prediction ATS: Minnesota

Miami Dolphins (+2) at Buffalo Bills

Bills coach Sean McDermott won’t say if he will rest any of the team’s starters. Buffalo has little on the line since they are guaranteed to get either the No.2 or No.3 seed and will play on Wild-Card Weekend regardless of Sunday’s outcome. The Dolphins need a victory for a chance to make the playoffs, and even if the Bills take this game seriously, Miami is good enough to win it outright.

Prediction ATS: Miami

Baltimore Ravens (-13) at Cincinnati Bengals

All season long, the Ravens have been blowing out bad teams. Coming off a 27-13 win over the Giants, Baltimore has beaten six teams that have losing records by at least 14 points. A win gets the Ravens into the playoffs.

Prediction ATS: Baltimore

Pittsburgh Steelers (+9) at Cleveland Browns

Steelers coach Mike Tomlin announced Ben Roethlisberger won’t start, and Pittsburgh has virtually nothing to play for with the AFC North title wrapped up. That doesn’t mean the Steelers’ players that are on the field will just hand their rivals a playoff berth. Pittsburgh has won plenty of games this season with average quarterback play, so this could be a competitive game if Mason Rudolph avoids making costly turnovers.

Prediction ATS: Pittsburgh

Dallas Cowboys (-1.5) at New York Giants

It seems that every time an NFC East team starts to play well, it disappoints shortly thereafter. The Cowboys are on a three-game winning streak against all bad teams. New York’s woeful offense can find at least some success against Dallas’ 30th-ranked scoring defense.

Prediction ATS: New York

Atlanta Falcons (+6.5) at Tampa Bay Buccaneers

Tampa Bay still has something to play for since a victory would assure them a first-round playoff matchup with the lowly NFC East winner. The Bucs outscored the Falcons 31-10 in the second half of their Week 15 matchup. Tampa Bay’s offense might be coming together at just the right time.

Prediction ATS: Tampa Bay

Green Bay Packers (-5.5) at Chicago Bears

Mitchell Trubisky might be playing the best football of his career, but the same could be said for Aaron Rodgers. Look for Green Bay’s quarterback to clinch both the MVP award and a first-round bye.

Prediction ATS: Green Bay

Tennessee Titans (-7.5) at Houston Texans

Tennessee’s defense can’t seem to stop any decent quarterback. Eliminate games against the Jaguars and Bears and the Titans have allowed an average of 31.6 points over a nine-game stretch. That includes a 42-36 victory over Deshaun Watson and the Texans. Sunday could be another close shootout.

Prediction ATS: Houston

Los Angeles Chargers (-3.5) at Kansas City Chiefs

With the No.1 seed already locked up, the Chiefs will start Chad Henne in place of Patrick Mahomes. That could mean stars like Tyreek Hill and Travis Kecle are also going to sit. The Chargers could have a significant talent advantage at the game’s most important positions.

Prediction ATS: Los Angeles

New Orleans Saints (-6.5) at Carolina Panthers

Carolina has been feisty against some of the best teams on their schedule. The Panthers covered the spread against the Packers, Chiefs and Saints, who narrowly beat Carolina by a field goal earlier this season. With only an outside chance of getting the No.1 seed, New Orleans could see the scores around the league in the second half and realize they have nothing to play for.

Prediction ATS: Carolina

Arizona Cardinals (-3) at Los Angeles Rams

Jared Goff won’t start at quarterback for the Rams, and it appears there’s a good chance Kyler Murray will overcome his leg injury and take snaps for the Cardinals. Goff is not an elite quarterback, but his value to Los Angeles will be quite evident when it’s John Wolford that’s trying to help the team clinch a playoff spot.

Prediction ATS: Arizona

Seattle Seahawks (-6) at San Francisco 49ers

Seattle defeated San Francisco by 10 points earlier this season when Jimmy Garoppolo was healthy and the 49ers were in the playoff hunt. Russell Wilson only needs to defeat C.J. Beathard by a touchdown to cover this spread as Seattle fights for the No.1 seed and San Francisco plays with nothing on the line.

Prediction ATS: Seattle

Las Vegas Raiders (-2.5) at Denver Broncos

The Raiders embarrassed the Broncos 37-12 when they met earlier this season. Including that loss, Denver has only scored more than 20 points once in its last seven games. Las Vegas blew its postseason hopes, but Derek Carr and Co. can still move the ball better than most NFL offenses.

Prediction ATS: Las Vegas

Jacksonville Jaguars (+14) at Indianapolis Colts

The Jaguars did find a way to upset the Colts in the season opener. Indianapolis should win the rematch, but they’ll get Jacksonville’s best effort now that the Jaguars have already locked up the No.1 overall pick in the draft.

Prediction ATS: Jacksonville

Washington Football Team (-1.5) at Philadelphia Eagles

Alex Smith is likely to start for Washington, though it’s unclear how healthy the quarterback will be. Washington’s offense might not be able to take advantage of the Eagles’ secondary the way other opponents have in recent weeks. Even in defeat, Jalen Hurts has been impressive for Philadelphia, and he gives the Eagles a great chance to play spoiler in the season finale.

Prediction ATS: Philadelphia

Green Bay quarterback Aaron Rodgers throws a pass in the Packers' NFL victory over the Detroit Lions
Green Bay quarterback Aaron Rodgers throws a pass in the Packers' NFL victory over the Detroit Lions GETTY IMAGES NORTH AMERICA / Gregory Shamus