Last week's earthquake and tsunami in northern Japan and its aftermath in the form of nuclear reactor crisis present a near-term disruption for a handful of software companies that have exposure to the region.

Japan is the third-largest economy in the world and one of the largest trading partners of the U.S., so any long term disruption should ripple through the U.S. and the global economy.

We think the worst-case scenario at this point would be if Tokyo were to shut down because of dangerous radiation levels. This would have global repercussions and result in a slowdown of the global economy, FBR Capital Markets analyst David Hilal wrote in a note to clients.

Impact On Adobe Systems (NASDAQ: ADBE)

Japan represents Adobe's second-largest market. Adobe generates 20 percent ofits revenues from Asia-Pacific and about 10 percent to 15 percent of its revenues from Japan.

The analyst noted that since the earthquake occurred in March, the analyst do not expect any impact on the first quarter 2011 ended in February, the results of which will be reported next week.

However, we think the company's guidance will likely be negatively impacted as the company takes the impact of the earthquake and its aftermath into consideration, Hilal wrote.

Shares of Adobe closed Tuesday's regular trading session at $33.04 on Nasdsaq.