Favorites have had a losing record against the spread in every week of the 2021 NFL season. Week 4 includes a bunch of heavy underdogs. Nearly half the games feature a point spread of at least seven points.

Here are picks against the spread for every game in Week 4, as well as updated betting odds. Betting lines come from FanDuel Sportsbook.

Jacksonville Jaguars (+7.5) at Cincinnati Bengals

As bad as Jacksonville has been, it’s difficult to lay more than a touchdown with Cincinnati. The Jaguars at least kept their game against the Cardinals within single digits until halfway through the fourth quarter. The Bengals have more work to do to prove that they are a decent team.

Prediction ATS: Jacksonville

Washington Football Team (-1.5) at Atlanta Falcons

In a matchup between a pair of 1-2 teams that probably aren’t going anywhere, taking the points with the home underdog is the best bet. Taylor Heinicke didn’t inspire confidence with his two interceptions in a 22-point Week 3 loss.

Prediction ATS: Atlanta 

Detroit Lions (+3) at Chicago Bears

Justin Fields and Andy Dalton have both been a disaster under center for Chicago. The Lions could easily have the best quarterback in this game in Jared Goff. Detroit has been competitive against three contenders and probably should’ve upset Baltimore in Week 3.

Prediction ATS: Detroit

Tennessee Titans (-7.5) at New York Jets

If the Jets can’t put up some points in Week 4, they might be hopeless this season. New York has exclusively faced top-five defenses. Only seven teams have given up more points than Tennessee. Zach Wilson can only improve after seven interceptions and 15 sacks in his first three NFL games.

Prediction ATS: New York

Cleveland Browns (-2.5) at Minnesota Vikings

Kirk Cousins has been terrific to start the season, throwing for 918 yards, eight touchdowns, no interceptions and a 118.3 passer rating. Minnesota’s offense should keep rolling at home, where the team is very difficult to beat. Cleveland might not quite have the firepower to keep up without Jarvis Landry.

Prediction ATS: Minnesota

Indianapolis Colts (+1.5) at Miami Dolphins

This is probably going to be an ugly game between a pair of offenses that aren’t very good. Miami has the edge at home with a defense that continues to force turnovers. Carson Wentz hasn’t improved enough from his disastrous 2020 campaign to make the Colts a playoff contender.

Prediction ATS: Miami 

Carolina Panthers (+4.5) at Dallas Cowboys

After a 3-0 start, Carolina plays its first road game against a good team. Injuries to Christian McCaffrey and Jaycee Horn will make it tough for the Panthers to keep up with the Cowboys. Dallas’ top-five offense is for real, while Carolina’s top-10 offense is due to regress.

Prediction ATS: Dallas

New York Giants (+7.5) at New Orleans Saints

The Giants will likely find a way to lose this game, but they’ve got a chance to keep it close for most of the way. New York has lost two straight games in heartbreaking fashion by four total points. The Saints have been the NFL’s most unpredictable team in 2021, winning two games by 50 combined points and suffering their one loss by 19 points.

Prediction ATS: New York

Kansas City Chiefs (-7.5) at Philadelphia Eagles

With the line moving past a touchdown, the Eagles are probably on the right side. Kansas City is still the much better team, but the Chiefs' defense gives Philadelphia a chance to keep this game close and potentially secure a backdoor cover.

Prediction ATS: Philadelphia

Houston Texans (+16.5) at Buffalo Bills

Buffalo is going to win this game. The margin of victory is the only question. Houston has been competitive, and Davis Mills exceeded extremely low expectations in his first start.

Prediction ATS: Houston

Arizona Cardinals (+6) at Los Angeles Rams

The Rams might be the best team in the NFC after beating the Bucs, but the Cardinals can win this game outright. Arizona was more impressive than L.A. in the first two weeks. Kyler Murray gives Arizona’s offense one of the highest ceilings in the league. This is going to be a tough divisional game that comes down to the wire. 

Prediction ATS: Arizona

Seattle Seahawks (+3) at San Francisco 49ers

Betting on Russell Wilson as an underdog of at least a field goal is usually a good idea, even with Seattle’s poor defense. The quarterback leads the league with a 133.6 passer rating and 10.4 yards per attempt. San Francisco has a vulnerable secondary.

Prediction ATS: Seattle 

Baltimore Ravens (+1) at Denver Broncos

This might be the most difficult Week 4 game to predict. The Broncos are undefeated, but they’ve only played winless teams. Two of Baltimore’s games were decided on the final play, and the other was a one-point contest. Maybe home-field advantage allows Denver to pull out another win.

Prediction ATS: Denver

Pittsburgh Steelers (+7) at Green Bay Packers

Pittsburgh’s offense is broken with Ben Roethlisberger at quarterback. An uncreative, short passing attack has resulted in the Steelers averaging fewer than 19 points per game over their last nine regular-season contests. A banged-up defense can only do so much against Aaron Rodgers and Davante Adams.

Prediction ATS: Green Bay

Tampa Bay Buccaneers (-7) at New England Patriots

Tom Brady’s return to New England should be a successful one for the greatest quarterback of all time. It might feel like a home game for Brady and the Bucs, and Tampa Bay already has a significant edge on offense over the Patriots. Bill Belichick won’t have much success slowing down Brady, who is the league’s No. 2 passer and has a 109.7 passer rating.

Prediction ATS: Tampa Bay

Las Vegas Raiders (+3.5) at Los Angeles Chargers

There’s nothing fluky about the Raiders’ 3-0 start. Las Vegas has defeated a pair of good defenses and the Ravens, who boast a top-four offense. The point spread shouldn’t be more than a field goal since the Raiders’ fans in attendance might make Monday feel like a home game for Las Vegas.

Prediction ATS: Las Vegas

Season Record: 24-23-1

Ezekiel Elliott Dallas Cowboys Ezekiel Elliott #21 of the Dallas Cowboys runs against the Arizona Cardinals during the second quarter at AT&T Stadium on October 19, 2020, in Arlington, Texas. Photo: Ronald Martinez/Getty Images