Alcohol was allegedly involved in the incident.
Details surrounding the arrest are unclear -- but sources tell us, it was alcohol-related. We're told Matthew was en route to a fast food restaurant for some late night eats at the time of his arrest, TMZ reported.
The Lost actor was taken into custody and released.
If alcohol was indeed involved, it was a case of life imitating art.
Fox's popular Lost' character, Dr. Jack Shephard, struggled with alcoholism after he and the remaining Losties were rescued from the mysterious island.
Sporting a disheveled beard, he uttered the famous line, We have to go back, Kate! to Kate [Evangeline Lilly] during the finale of the third season of Lost and it was evident that his character was facing problems with alcohol and drugs. The finale shocked audiences by revealing that the Losties were rescued from the island.
The run-in with the law Friday is the second for Fox in nine months.
A Cleveland bus driver accused him of assault, battery and infliction of emotional distress in another incident allegedly fueled by alcohol, People magazine reported.
Fox is a resident of Bend, Ore.
Matthew Fox was a trending topic on Twitter Monday afternoon as word spread of his arrest.
Some Lost fans mocked Fox on the micro-blogging site.
Matthew Fox getting a DUI is actually pretty hilarious if you've seen Lost #WEHAVETOGOBACK, tweeted William Joy.
Poor Matthew Fox, he just wants to go baaaaack to the island..., said @batclaw.
Matthew Fox is looking for Evangeline Lilly. We have to back, Kate! WE HAVE TO GO BACK! #Lost #DUI QQ, said Francisco Fontanilla.
Others had some sincere advice for the former Party Of Five cast member.
Matthew Fox, please stop drinking, tweeted Rebecca Johnson.