The Manning brothers are set to meet for the third time in their NFL careers. The Denver Broncos will visit the New York Giants in Week 2 of the 2013 season.

The first two matchups did not go in Eli’s favor. Peyton and the Indianapolis Colts beat the Giants in their only meeting since his brother entered the league. Now, Eli and New York will host Peyton as a member of the defending AFC West champs.

The contest is one of the four late-games, starting at 4:25 p.m. ET. CBS will have the coverage, but viewers can watch a live stream online with NFL Sunday Ticket Max.

No one looked better in their season debut than Peyton Manning. The 2012 MVP runner-up threw seven touchdowns against the defending champion Baltimore Ravens in the season opener. He finished the game with 462 passing yards on 42 attempts, and a near-perfect 141.1 quarterback rating. Three different receivers caught two touchdown passes, including Wes Welker who had nine receptions in his first regular season game as a Bronco.

Eli Manning wasn’t nearly as good in Week 1. While he did throw for two scores and only his brother had more passing yards in the opening weekend, three picks from Giants quarterback played a major role in their loss to the Dallas Cowboys. Overall, New York committed six turnovers on the night.

Denver began the season as the favorites to win the Super Bowl, and those odds only got better after they looked so good in game No.1. Their stellar performance and the Giants lackluster play has made the Broncos decided favorites on the road. They are giving New York 3.5 points at MetLife Stadium.

Prediction: It would be easy to overreact after Week 1. The Broncos offense looked unstoppable, while the Giants looked like they could be heading for a last place finish. However, New York will likely improve upon last week’s debacle. They should cut down on their turnovers and Peyton won’t throw for seven more scores. New York has a habit of playing better against the top competition. They have a good chance to pull off the upset.

Final Predicted Score: New York 34, Denver 31