Pop newcomer Ke$ha took her first solo chart single TiK ToK to the top of the Billboard Hot 100 singles chart Wednesday.

She becomes the first female vocalist to rise to No. 1 with her debut single since Lady Gaga stormed the list with Just Dance in January 2009.

TiK ToK is actually the second Hot 100 No. 1 to feature vocals by the 22-year-old. She had a non-credited appearance on Flo Rida's six-week chart-topper Right Round earlier this year. TiK ToK is the first single from Ke$ha's debut album, Animal, which is set for a January 5 release.

Ke$ha ended the five-week run of Empire State of Mind, which slipped to No. 2. In a rare chart occurrence, an acoustic version of Empire by Keys debuted at No. 55. Different takes of a song are usually merged with the original versions for the purpose of chart rankings, but when a contributing vocalist (Keys) takes the reins without help from the lead act (Jay-Z), the songs are tracked separately.

No new tracks entered the top 10 for a third straight frame, the longest stretch in almost six years. Lady Gaga's Bad Romance held at No. 3, and the next four rankings were also unchanged: Iyaz's Replay at No. 4, Owl City's Fireflies at No. 5, Sexy Chick by David Guetta featuring Akon at No. 6, and Jason Derulo's Whatcha Say at No. 7.

Jay Sean's Down rebounded two to No. 8, while the Black Eyed Peas slipped one to No. 9 with Meet Me Halfway. Britney Spears' 3 fell one to No. 10.

Eminem claimed the chart's top debut, coming in at No. 29 with Hell Breaks Loose. The song features Dr. Dre and is one of the new tracks that appear on Eminem's re-released Relapse: Refill. Another new cut, Elevator, debuted at No. 67.