The 2022 NFL regular season is coming down to the wire, making Week 16 a must-win situation for several teams. Thirteen teams are outside of the Week 16 playoff picture and have yet to be eliminated from contention. Five of those teams are favored in their next game, according to the latest odds.

Here are picks against the spread for every game in Week 16 and updated betting odds from FanDuel and DraftKings Sportsbook.

Jacksonville Jaguars (-1.5) at New York Jets

Even with Zach Wilson under center, the Jets should probably be short favorites at home. Wilson and the Jets nearly beat the red-hot Lions in Week 15, blowing the lead with less than two minutes remaining. The Jaguars haven't yet earned the right to be trusted on the road against a playoff contender.

Prediction ATS: New York

New York Giants (+3.5) at Minnesota Vikings

A bad Minnesota pass defense has forced the Vikings to play a ton of close games this season. The Giants are unlikely to take advantage of Minnesota's poor coverage in the secondary. Daniel Jones has been limited to fewer than 229 passing yards 18 of his last 19 starts.

Prediction ATS: Minnesota

New Orleans Saints (+3) at Cleveland Browns

Betting against the Saints on the road has been a winning strategy in 2022. New Orleans is 0-5 straight up and 1-4 against the spread in its last five road games. The Browns are 3-1 in their last four games, giving up 14.3 points per game.

Prediction ATS: Cleveland

Detroit Lions (-2.5) at Carolina Panthers

The Lions' only loss in their last seven games came at the hands of the AFC's No. 1 seed on a last-second field goal. The Panthers, which have a 2-8 record outside of the division, are not going to be the team that slows down Detroit in its path to the playoffs.

Prediction ATS: Detroit

Cincinnati Bengals (-3.5) at New England Patriots

Despite their embarrassing loss in Las Vegas, the Patriots still control their own destiny and can sneak their way into the playoffs. New England leads the AFC in sacks. Look for Bill Belichick to put Matthew Judon and Josh Uche in positions to take advantage of a still shaky Cincinnati offensive line.

Prediction ATS: New England

Buffalo Bills (-8.5) at Chicago Bears

Justin Fields is the whole Bears team at this point, and it won't be enough to challenge the top team in the AFC. Chicago's quarterback is without his best receiver and offensive lineman. The Bears are giving up 32.3 points per game during their seven-game losing streak.

Prediction ATS: Buffalo

Houston Texans (+5.5) at Tennessee Titans

The Texans might end up being the biggest upset winner on the Week 16 schedule. Houston has come just shy of upsetting Dallas and Kansas City in back-to-back weeks. It sounds like Ryan Tannehill probably won't start for the Titans, forcing Tennessee to turn to Malik Willis and his 47.8 passer rating.

Prediction ATS: Houston

Seattle Seahawks (+9.5) at Kansas City Chiefs

For the last two years, the Chiefs have consistently won straight up but lost against the spread. Kansas City is 17-28 against the spread in its last 45 games, including the playoffs. The Chiefs only have one victory by more than six points in the last five contests.

Prediction ATS: Seattle

Atlanta Falcons (+7.5) Baltimore Ravens

With or without Lamar Jackson under center, Baltimore's offense has been underwhelming. The Ravens last scored more than 27 points in Week 3. In their last seven games, the Falcons have lost by more than six points just once.

Prediction ATS: Atlanta

Washington Commanders (+7) at San Francisco 49ers

The 49ers are beating teams with ease during their seven-game winning streak. The average score during San Francisco's unbeaten stretch is 28-11. Washington is 26th in yards per play and could struggle mightily against the league's No. 1 defense.

Prediction ATS: San Francisco

Philadelphia Eagles (+5.5) at Dallas Cowboys

The Cowboys were 1.5-point favorites before it appeared that Jalen Hurts would be out with an injured shoulder. Philadelphia is good enough to upset Dallas with Gardner Minshew at quarterback. The Eagles' offensive line can keep the Cowboys' pass rush at bay. Dak Prescott has seven interceptions in the last four games.

Prediction ATS: Philadelphia

Las Vegas Raiders (+2.5) at Pittsburgh Steelers

Taking the points is probably the best option in this game. The Raiders have won four of the last five games and would be in the thick of the playoff race if they hadn't inexplicably blown a late two-touchdown lead in Los Angeles. Pittsburgh's offense is one of the few that Las Vegas can likely keep from making a second-half comeback.

Prediction ATS: Las Vegas

Green Bay Packers (+4) at Miami Dolphins

The Packers are still in the playoff hunt because they beat up on the NFC's two worst teams. Green Bay has consistently been defeated by the toughest opponents on its schedule. The Dolphins' playmakers will take over this game in Miami, where Tua Tagovailoa is undefeated as a starter this season.

Prediction ATS: Miami

Denver Broncos (-1.5) at Los Angeles Rams

This version of the Rams' offense can barely put up points against an average defense, let alone the Broncos' No. 3 ranked scoring defense. Outside of their miraculous comeback in the final minutes against Las Vegas, Los Angeles' offense has scored 15 points in 116 minutes of game time since acquiring Baker Mayfield.

Prediction ATS: Denver

Tampa Bay Buccaneers (-6.5) at Arizona Cardinals

The Buccaneers shouldn't be favored by close to a touchdown on the road against anyone. Arizona could have trouble scoring, but Tampa Bay probably won't win by seven points with the way it's been playing. The Buccaneers have gone 10 straight games without scoring more than 23 points.

Prediction ATS: Arizona

Season Record: 109-111-4

CeeDee Lamb, Dallas Cowboys
CeeDee Lamb #88 of the Dallas Cowboys runs against the Arizona Cardinals during the fourth quarter at AT&T Stadium on October 19, 2020, in Arlington, Texas. Ronald Martinez/Getty Images