With the 2022 midterm elections 14 days away, the two Pennsylvania senate candidates square off Tuesday in Harrisburg in their sole debate.

Pennsylvania Lt. Gov. John Fetterman, the Democratic nominee, and Republican Dr. Mehmet Oz are vying for the seat of the retiring Sen. Pat Toomey, a Republican. The winner could tip the balance of power in the Senate.

Here's what you need to know.

The hour-long debate airs at 8 p.m. ET. The debate will not feature a live audience but 30% of voters say they are very likely to tune in, according to a CBS poll.

The debate will be moderated by WHTM news anchor Dennis Owens and WPXI anchor Lisa Sylvester and shown on nine Nexstar Pennsylvania stations listed below:

  • WPHL-TV: Philadelphia
  • WPXI-TV: Pittsburgh
  • WTAJ-TV: Johnstown, Altoona, State College
  • WYOU-TV: Scranton, Wilkes-Barre, Hazleton
  • WBRE: Scranton, Wilkes-Barre, Hazleton
  • WHTM-TV: Harrisburg, Lancaster, Lebanon, York
  • WJET-TV: Erie
  • WFXP-TV: Erie
  • WYTV-DT: Youngstown, Ohio

The debate will also be broadcast on radio stations across the state and online on the station's websites. A live stream can be seen here.

The Republican candidate hosts a talk show, The Dr. Oz Show, which aired for 13 seasons on ABC before moving to the Oprah Winfrey Network. Oz beat his primary opponent, David McCormick, in May by a mere 951 votes after an automatic recount.

Fetterman served 13 years as mayor of Braddock, and has served as the state's lieutenant governor since 2019. Fetterman cruised through the Democratic primary, winning 58% of the vote.

Oz has called Fetterman's agenda "radical, deadly, wrong" in an ad campaign and has attacked his opponent's agreement to only one debate. Fetterman initially campaigned on a minimum of three debates. But after suffering a stroke on the campaign trail, Fetterman agreed to just one debate.

Fetterman's health has drawn attention, though his physician said he is recovering well. He suffers from "an auditory processing disorder which can come across as hearing difficulty," according to his physician in a letter released early last week.

Fetterman will rely on closed captioning for the moderator's questions and Oz's responses.

The debate is likely to focus on issues such as abortion, gas prices, fracking and immigration.

The two candidates stand opposed on several issues. Fetterman has stated plans to modernize the path to citizenship including alterations to the current visa and asylum programs.

Oz, who was endorsed by former President Donald Trump, has criticized President Joe Biden's immigration policies and supports securing the border "with a barrier – whether that is a physical wall or one patrolled by technological advances," according to his campaign website.

Oz is "100% pro-life" while Fetterman supports The Women's Health Protection Act, a bill to codify legal abortion access.