David Letterman
David Letterman (right) interviews Tom Hanks on "The Late Show with David Letterman" Monday. Letterman's last show will air on CBS on Wednesday. CBS

In a week of big television good-byes -- “Mad Men” aired its series finale Sunday -- and season finales, David Letterman will end his 22-year run on CBS’ “The Late Show with David Letterman” Wednesday. Letterman’s plans for the big send-off have been kept under wraps, but the half-week curtain call is already off to an epic start.

The last episode of “The Late Show with David Letterman” will air Wednesday at 11:35 p.m. EDT on CBS. No guests or musical performers have been announced, and CBS’ description of the show teases only memorable highlights from the past two decades and the final “Top 10” list. However, Letterman has already been busy going out in style.

Monday's episode kicked things off with a bang, as Dave welcomed Oscar winner Tom Hanks as his only interview guest. The two took a selfie together and chatted about Hanks upcoming movie, “Inferno,” directed by Ron Howard and co-starring Felicity Jones.

Watch Hanks show Letterman how to use a selfie stick in the clip below:

However, the real treat came at the end of the episode, when Eddie Vedder of Pearl Jam performed his band’s 1994 hit “Better Man” with Paul Shaffer and the CBS Orchestra. Vedder gave an energetic and emotional performance, and Letterman seemed visibly moved, hugging the rock star after the song.

Watch Vedder’s performance below:

Things will keep on rolling Tuesday, as Bill Murray will return to “The Late Show” as Letterman’s final confirmed guest. The appearance will bring Letterman’s CBS tenure full circle -- Murray was the host’s first guest on the show in 1993. On the music side, Bob Dylan will appear, ending a nearly 20-year absence from “The Late Show."

What will Letterman do in his final show Wednesday? Fans will have to wait to find out.

Will Letterman have a surprise guest on Wednesday? Tweet your thoughts to @Ja9GarofaloTV.