Liv (Rose McIver) and Dr. Ravi (Rahul Kohil) shared happier times in "iZombie" Season 1. When Season 2 premieres, Liv will find herself isolated and relying on her worst enemy, Blaine (David Anders, not pictured). CW

Following the crushing Season 1 finale of “iZombie,” the show’s leading star, Liv (Rose McIver) will find herself in the worst predicament of all in Season 2. The circle of friends she kept at length will abandon her. Worse yet, Liv will be forced to team up with the heartless former zombie, Blaine (David Anders).

In an interview with “iZombie” and “Veronica Mars” showrunner Rob Thomas, he revealed Liv is going to see her friends and loved ones fall away from her as Season 2 begins. After her roommate Peyton (Aly Michalka) ran off and Major (Robert Buckley) became cross with her for turning him into a zombie, she might further distance her brother and mother for refusing a potential zombie contaminated transfusion.

Thomas told The Hollywood Reporter, “Everyone who was in that intervention scene in the pilot — Peyton, her mom, her brother and Major — everyone who was trying to pull her out of her doldrum at the beginning of season one, she will be estranged from as we begin season two.”

But that’s not all that’s in store for the “iZombie” star. After curing murderous zombie kingpin Blaine with a yet untested vaccine, Liv and Blaine will be forced to call a truce and work together to defeat the season finale baddie, Max Rager CEO Vaughn Du Clark (Steven Weber). “It’s not as though they’re going to become buddies, but they will need to work together to survive,” assured Thomas, pointing out that Blaine’s past life hobby of murdering homeless teens would not endear him to Liv.

At the end of Season 1 finale, “Blaine’s World,” Liv confronted Rager. Now, with a price on her head and those of other zombies, Liv will have to make peace with Blaine in order to fight back. Then there’s the tricky temptation of Dr. Ravi’s (Rahul Kohli) cure that saved both Blaine and Major from their zombie state. Will Liv partake or will she hold off until the cure’s been perfected? Fans will have to wait until "iZombie" Season 2 to find out.

“iZombie” returns to the CW this fall. New episodes will air Tuesdays at 9 p.m.