The Dallas Cowboys and Los Angeles Chargers are favored on the road in the first round of the 2023 NFL playoffs. The San Francisco 49ers and Buffalo Bills have to win by double digits on Wild-Card Weekend in order to cover the point spread. The Cincinnati Bengals and Minnesota Vikings are favored by less than a touchdown at home.

Here are picks against the spread for all the first-round playoff games. The latest betting odds are from FanDuel and DraftKings Sportsbook.

Seattle Seahawks (+10) at San Francisco 49ers

San Francisco thoroughly outplayed Seattle in their two regular-season meetings. The 49ers blew out the Seahawks 27-7 at home in Week 2. Seattle's only points came from a blocked field goal that was returned for a touchdown. The 49ers led the Seahawks by 15 points in their Week 15 matchup before a late Geno Smith touchdown pass made the final score 21-13. San Francisco is the league's hottest team with a 10-game winning streak.

Prediction ATS: San Francisco

Los Angeles Chargers (-1) at Jacksonville Jaguars

The Chargers and Jaguars had the most lopsided regular-season result of all the wild-card rematches. Jacksonville blew out Los Angeles 38-10 in Week 3. Justin Herbert was fresh off a rib injury and should be much better Saturday. Trevor Lawrence had three touchdown passes and no interceptions in the victory. It's much less certain that the Chargers' defense will be improved in the playoffs. The Jaguars are averaging 29.2 points during their five-game winning streak.

Prediction ATS: Jacksonville

Miami Dolphins (+10.5) at Buffalo Bills

Despite the uncertainty at quarterback, the Dolphins are probably the right pick with the line north of 10 points. The Dolphins beat the Bills in Week 3 and lost a nail-biter in Buffalo in Week 15, even though Tua Tagovailoa wasn't particularly impressive in either contest. During Miami's recent five-game losing streak, only one of its defeats came by more than six points. Four of Buffalo's victories during its seven-game winning streak have come by single digits.

Prediction ATS: Miami

New York Giants (+3) at Minnesota Vikings

The Vikings needed a last-second, 61-yard field goal to hold off the Giants 27-24 on Christmas Eve. New York will likely be a popular pick, given how well it played in Minnesota and the Vikings' negative point differential during the season. It could be a different story, however, in Daniel Jones' first playoff start. The Giants' quarterback had fewer than 200 passing yards in 10 of his 16 starts. Winning a road playoff game that way will be difficult. Minnesota is tied for a league-best 8-1 home record. Justin Jefferson had 12 catches against the Giants, and he could be the difference maker in this one.

Prediction ATS: Minnesota

Baltimore Ravens (+6.5) at Cincinnati Bengals

Lamar Jackson hasn't practiced in five weeks. There's a good chance that Jackson won't be ready to play in Cincinnati, and if he does take the field, the quarterback might not be close to 100%. In the five games that backup quarterback Tyler Huntley has either started or taken the majority of the snaps, Baltimore is averaging 11.8 points per game. That's not going to cut it against Joe Burrow and the Bengals, which are averaging 29.0 points during an eight-game winning streak.

Prediction ATS: Cincinnati

Dallas Cowboys (-3) at Tampa Bay Buccaneers

Picking against Tom Brady as a home underdog in the playoffs doesn't seem like a smart idea when he's not facing a top Super Bowl contender. The Cowboys have been playing shaky football for over a month, culminating with a 26-6 loss in Week 18. Dak Prescott missed five games and still tied for the league-lead with 15 interceptions. Prescott completed less than half of his passes in Tampa Bay's 19-3 win in Dallas in the season opener.

Prediction ATS: Tampa Bay

Joe Burrow Ja'Marr Chase Cincinnati Bengals
Joe Mixon #28 and Joe Burrow #9 celebrate with wide receiver Ja'Marr Chase #1 of the Cincinnati Bengals after Chase scored a second half touchdown against the Baltimore Ravens at M&T Bank Stadium on October 24, 2021 in Baltimore, Maryland. Rob Carr/Getty Images