Futures on major U.S. indices remained range-bound on Wednesday ahead of key weekly U.S. jobs data and September trade balance reports from the government.

Futures on the S&P 500 are up 0.04 percent, futures on the Dow Jones Industrial Average are up 0.01 percent and Nasdaq100 futures are up 0.07 percent.

Investors are likely to focus on weekly initial jobless claims, September trade balance and monthly import price index reports which are due to be released before the markets open, while crude inventories and natural gas storage data will be released after market opens.

The Department of Labor is due to report the initial jobless claims data before the opening bell. Economists forecast initial jobless claims to be 450,000 for the week ended November 6 against 457,000 of the previous week. Any data that is weaker than expected will weigh on market sentiments.

US trade deficit is expected to narrow in September as US dollar continued to slide against major counterparts. Economists are forecasting that trade deficit in September will narrow to $45 billion from $46.30 billion in the previous month.

US stocks ended lower on Tuesday as investors continued to mull over the Federal Reserve's latest effort to stimulate the economy by purchasing $600 billion in government debt over the coming months.

The euro advanced 0.24 percent to 1.3806 against the dollar and the yen declined 0.07 percent against the greenback.

Crude futures are currently trading at $86.72/barrel ahead of inventory data while gold futures declined 0.47 percent.

European stock markets are currently trading lower with FTSE 100 down by 11.85 points, DAX30 down by 17.22 points and CAC 40 down by 18.08 points.