Frank Gore San Francisco 49ers
Running back Frank Gore, left, and the 49ers square off against the New Orleans Saints on Sunday afternoon. Reuters

Two games in particular standout this week, with the San Francisco 49ers heading to the Big Easy for a date with the New Orleans Saints, and the Kansas City Chiefs fighting the altitude against the Denver Broncos.

K.C. can put Denver in a big hole in the AFC West and remain the NFL’s lone undefeated team, likely forcing the Broncos to win out for the No. 3 seed when it looked like they were destined to host throughout the playoffs. The Broncos also have to worry about injured Peyton Manning against the Chiefs' No. 1 pass rush.

New Orleans and San Francisco also face serious division implications. The hard-charging Carolina Panthers are only one-game behind the Saints in the NFC South, and a loss for the 49ers could put them in a tie for second in the NFC West with Arizona.

Check out the predictions below for both games, and all the rest in Week 11.

Byes: Dallas, St. Louis

Indianapolis -3 at Tennessee +3

How the Colts respond from their Week 10 meltdown could define the rest of the season. The Titans have an even more potent defense than St. Louis, and are probably a little angry they gave previously winless Jacksonville their first victory of the season.

Time: Thursday, 8:25 p.m. ET

Channel: NFL Network

Prediction: Indianapolis 24, Tennessee 17

N.Y. Jets +1 at Buffalo -1

The Jets have gone 4-1 in their last five meetings with Buffalo, and sacked EJ Manuel eight times earlier this season. Buffalo also forced two turnovers, but let up a huge 69-yard touchdown in the 27-20 loss. This game will come down to the wire and the Bills will hurt N.Y.’s playoff shot.

Time: Sunday, 1 p.m. ET

Channel: CBS

Prediction: Buffalo 17, New York 10

Cleveland +6 at Cincinnati -6

The Browns are fresh off the bye week, and are still poised for a playoff berth with arguably the AFC's most balanced defense. Failing to take a commanding lead in the AFC North, Cincinnati couldn’t convert a miracle play into a victory, and Cleveland held them to two field goals earlier this year. -

Time: Sunday, 1 p.m. ET

Channel: CBS

Prediction: Cleveland 20, Cincinnati 17

Baltimore +3 at Chicago -3

Jay Cutler may have come back too soon, but he still nearly toppled Detroit in Week 10. Baltimore ended a three-game slide and may have some confidence in the AFC North after narrowly beating first-place Cincinnati. Running back Ray Rice needs to have a breakout game or the Ravens playoff chances are in serious doubt.

Time: Sunday, 1 p.m. ET

Channel: CBS

Prediction: Chicago 33, Baltimore 27

Washington +3.5 at Philadelphia -3.5

With Dallas on the bye, the Eagles and Nick Foles can improve their NFC East record and wrangle first place in the process. The Redskins need this victory to keep any postseason hopes alive, so desperation could play a role. Washington’s 26th ranked pass defense will try to be the first team to pick off Foles this season, while running backs Alfred Morris and LeSean McCoy could decide this game.

Time: Sunday, 1 p.m. ET

Channel: FOX

Prediction: Philadelphia 32, Washington 24

Detroit -3 at Pittsburgh +3

For what it's worth, since 2010, the Lions are 2-6 in the second of back-to-back road games. The Steelers have gone 3-2 in their last five games and field the league’s fourth best pass defense. If the Steelers can neutralize receiver Calvin Johnson and force some turnovers, they’ll pull out the win.

Time: Sunday, 1 p.m. ET

Channel: FOX

Prediction: Pittsburgh 24, Detroit 20

Atlanta -1.5 at Tampa Bay +1.5

Issues at running back would be of concern to Tampa Bay, but Atlanta’s 27th against the rush and has lost three straight. The Falcons have also averaged 11 points during their most recent slide.

Time: Sunday, 1 p.m. ET

Channel: FOX

Prediction: Tampa Bay 17, Atlanta 13

Arizona -7 at Jacksonville +7

Jags linebacker Paul Posluszny was named AFC Defensive Player of the Week, and Jacksonville finally got a notch in the win column. The Cards are one game out of the playoffs after winning two straight, so this could be a far more interesting matchup. How effectively the Cardinals can rush the ball should determine the outcome.

Time: Sunday, 1 p.m. ET

Channel: FOX

Prediction: Arizona 27, Jacksonville 17

Oakland +7 at Houston -7

Quarterback Case Keenum hasn’t tossed an interception yet, and Houston should end their losing streak either this week or next against Jacksonville. The Raiders nearly pulled out a win over the Giants, despite a paltry 213 total offensive yards. If the Raider play even just below their potential they can hang with most teams. If running back Darren McFadden comes back, the Raiders have an excellent chance for their first road win of the year.

Time: Sunday, 1 p.m. ET

Channel: CBS

Prediction: Oakland 30, Houston 24

San Diego -1.5 at Miami +1.5

The Dolphins rushed for two yards in Week 10 and lost by three points. San Diego had a 17-minute possession advantage, more rushing yards, and a better third down conversion rate than Denver, and still lost by eight points. These are two underachieving teams that should battle till the final whistle.

Time: Sunday, 4:05 p.m. ET

Channel: CBS

Prediction: San Diego 21, Miami 20

San Francisco +3 at New Orleans -3

The 49ers have won the last two meetings including the 2011 NFC Divisional round when Drew Brees threw two interceptions. But the Saints defense is far improved, and only Frank Gore looked effective in San Francisco’s loss to Carolina in Week 10. If New Orleans can contain Gore they’ll stay in line for the NFC’s No. 1 seed.

Time: Sunday, 4:25 p.m. ET

Channel: FOX

Prediction: New Orleans 28, San Francisco 20

Green Bay +6 at N.Y. Giants -6

Green Bay’s Aaron Rodgers is hoping to return before Thanksgiving, but for now Scott Tolzien will be under center against a Giants squad that’s recorded nine sacks during their three-game win streak. Three turnovers would have cost New York against most teams, but Oakland couldn’t capitalize. The Packers are far more capable of converting turnovers into points, and Eddie Lacy could chew up lots of clock.

Time: Sunday, 4:25 p.m. ET

Channel: FOX

Prediction: Green Bay 20, New York 17

Minnesota +12.5 at Seattle -12.5

The magic number for Minnesota seems to be 34, the number of points they’ve scored in both of the their victories. Seattle’s only let up 30 or more points once this season, its 34-28 loss to Indianapolis. Chances are the Seahawks pull out the victory against Percy Harvin’s old team.

Time: Sunday, 4:25 p.m. ET

Channel: FOX

Prediction: Seattle 34, Minnesota 20

Kansas City +8 at Denver -8

In the last three games, Peyton Manning’s been sacked eight times. The previous six games Manning was sacked five times. How well Denver protects the injured superstar should decide this matchup.

Time: Sunday, 8:30 p.m. ET

Channel: NBC

Prediction: Kansas City 20, Denver 17

New England +2.5 at Carolina -2.5

A sneaky good game with playoff implications. The Panthers boast the best total defense in the NFL, and the Patriots are refreshed after a bye week and 610 offensive yards, 413 coming in the air, against Pittsburgh’s fourth ranked secondary. The Panthers have allowed one team to rush for 100-plus yards, and that was back in Week Two. The Panthers own the second best winning streak in the league, and that should continue.

Time: Monday, 8:30 p.m. ET

Channel: ESPN

Prediction: Carolina 14, New England 10