With only six underdogs covering the point spread in Week 1 of the 2015 NFL season, gamblers got off to a great start and Las Vegas casinos lost a decent chunk of change. Sportsbooks are looking for better results in Week 2, which has seven 1-0 teams getting points in their second game of the year.

The Saints and Colts are the biggest favorites on the schedule, according to vegasinsider.com. One betting line has reached double-digits, and four favorites are giving their opponents less than a field goal.

Below are picks against the spread for every game in Week 2, as well as updated betting odds at Las Vegas casinos.

Denver Broncos (+3) at Kansas City Chiefs

It was only one game, but it’s looking like this could be the beginning of the end for Peyton Manning. The quarterback had trouble making deep passes, just like he did at the end of last year, throwing for just 175 yards on 40 attempts. Even if Manning was playing at a high level, the Chiefs are a playoff contender that would still have a good chance to win. After Denver wasn’t able to score an offensive touchdown in the opener, Kansas City is the safe pick at home, where they have covered the spread in six of their last seven games, according to Odds Shark.

Prediction ATS: Kansas City 

Houston Texans (+3) at Carolina Panthers

Whether it’s Brian Hoyer or Ryan Mallett starting at quarterback, the Texans could have a hard time scoring in Carolina. Houston scored 20 points against Kansas City, but 13 of those points came in the final minutes when the game was out of reach. The Panthers have won six of their last seven home games, and while Houston won four times on the road last year, none of those wins came against playoff teams.

Prediction ATS: Carolina

Tampa Bay Buccaneers (+10) at New Orleans Saints

The Saints might not be a playoff team, but they are still dangerous at home, especially against a team like the Bucs. Tampa Bay remains a team in transition, and could have trouble putting up points. Rookie Jameis Winston played poorly in Week 1, and may have similar struggles in New Orleans, playing behind one of the weakest offensive lines in football.

Prediction ATS: New Orleans

San Francisco 49ers (+5.5) at Pittsburgh Steelers

The 49ers surprised a lot of people when they beat the Vikings in the final game of Week 1, but they were fortunate to play a team that had an even worse first half then they did. Carlos Hyde thrived in the second half, but San Francisco’s offense failed to click for much of the game. With three extra days to rest, Pittsburgh has the advantage on Sunday, and should post a lot of points if DeAngelo Williams has another big game.

Prediction ATS: Pittsburgh

Detroit Lions (+3) at Minnesota Vikings

The Lions are 2-12 against the spread in their last 14 games as a road underdog. They had a golden opportunity to break the trend in Week 1, but they failed to hold a 21-3 lead. The Vikings have beaten the Lions 15 times in their last 17 tries in Minnesota, and Adrian Peterson appears poised to bounce back from an unproductive season opener.

Prediction ATS: Minnesota 

New England Patriots (-1) at Buffalo Bills

New England has been dominant against Buffalo during the Belichick-Brady Era. The Patriots have won 21 of their last 23 head-to-head matchups with the Bills, including 10 of their last 11 in Buffalo. While the Bills might have one of their best teams in recent seasons, they still start a career backup at quarterback, and Tyrod Taylor may need a standout game against a tough New England defense. Meanwhile, the Patriots are unlikely to lose the turnover battle 0-3 like Indianapolis did against Buffalo.

Prediction ATS: New England

Arizona Cardinals (-1.5) at Chicago Bears

The Cardinals have had a top-seven scoring defense in each of the last two seasons, and it looks like that will remain the case after the team held down Drew Brees and the Saints in the opener. Jay Cutler led the league in interceptions last season, and Arizona was tied for seventh in picking off opposing quarterbacks. The Bears went 2-6 at home last season, and the Cardinals have covered the spread in 10 of their last 14 games.

Prediction ATS: Arizona

Tennessee Titans (-1) at Cleveland Browns

The betting line has shifted more than a field goal in Tennessee’s favor, and this might be a justified overreaction from Week 1. While it was only one game, rookie quarterback Marcus Mariota looked like the real deal. Tennessee’s defense wreaked havoc on Jameis Winston last week, and they could do the same against Johnny Manziel, who has made a number of mistakes in his few starts. Home-field advantage doesn’t mean much here, since the Browns haven’t had a winning record in Cleveland since 2007.

Prediction ATS: Tennessee

San Diego Chargers (+3) at Cincinnati Bengals

The Bengals have gone under the radar for having one of the best home-field advantages in recent years. They haven’t lost at home to a team outside of the AFC North since 2012, and it’s been six years since the Chargers had a winning record on the road. Cincinnati has one of the NFL’s best pass defenses, and they won’t allow Philip Rivers to be the week’s top passer, like Detroit did in the opener.

Prediction ATS: Cincinnati

St. Louis Rams (-3.5) at Washington Redskins

The Redskins blew a chance to upset Miami last week, totaling nearly 100 more yards than the Dolphins. They were burned by a late punt return for a touchdown, while the Rams were aided by a return for a score of their own. If Washington can avoid any special teams’ blunders, they’ll have a chance to pull off the upset. The Redskins’ defense played well in Week 1, and St. Louis quarterback Nick Foles isn’t likely to match his 115.8 passer rating from last week.

Prediction ATS: Washington

Atlanta Falcons (+2.5) at New York Giants

The Giants had the most inexplicable loss of any team in Week 1. They created three turnovers against Dallas, and it’s hard to imagine them losing if they can do the same thing to Atlanta, who turned the ball over twice against Philadelphia. Odell Beckham was only targeted eight times in the opener, and that should change in Week 2, potentially giving the Giants their sixth win in seven tries against the Falcons.

Prediction ATS: New York

Baltimore Ravens (-6.5) at Oakland Raiders

No offense performed worse than Baltimore in the opener, and the Ravens should rebound in Week 2. Oakland allowed Cincinnati to score 33 points, and they could be missing both of their starting safeties on Sunday. Whether it’s Derek Carr or Matt McGloin at quarterback for the Raiders, they’ll struggle to put points on the board against a team they’ve beaten just once in 11 tries.

Prediction ATS: Baltimore

Miami Dolphins (-6) at Jacksonville Jaguars

No NFL team has more losses than the Jaguars in the past three seasons, and Jacksonville might be the league’s worst team in 2015. They have gone 9-40 since 2012, and only four of those losses have come by less than six points. Miami was lucky to cover the spread against Washington in Week 1, but assuming the Dolphins beat the Jaguars, they’ll likely win by at least a touchdown.

Prediction ATS: Miami

Dallas Cowboys (+5) at Philadelphia Eagles

Even though the Cowboys won and the Eagles lost in Week 1, the point spread has moved in favor of Philadelphia because of Dez Bryant’s injury. But Dallas is still good enough offensively to score against a weak Eagles pass defense. The Cowboys have covered the point spread in eight of their last nine road games, and the contest could be decided by a field goal with both teams having a chance to win late in the fourth quarter.

Prediction ATS: Dallas

Seattle Seahawks (+3.5) at Green Bay Packers

The Packers are looking for revenge after they blew a chance to go to the Super Bowl last year. They made several mistakes in the NFC Championship, and the Seahawks still needed overtime to get the victory. Playing without defensive coordinator Dan Quinn, who went to the Falcons this offseason, as well as safety Kam Chancellor, who is holding out, the Seattle defense was vulnerable in Week 1. Aaron Rodgers had a 140.5 passer rating on the road last week, and he’ll be difficult to slow down in Green Bay’s home opener.

Predictions ATS: Green Bay

New York Jets (+7) at Indianapolis Colts

The betting line doesn’t reflect what happened in Week 1, nor should it. After the Jets blew out the Browns and the Colts were dominated by the Bills, the two teams should play closer to their preseason expectations on Monday night. Ryan Fitzpatrick played well in the opener, which means he’s due for a bad performance. Andrew Luck’s 63.6 passer rating was lower than what he posted in all but two of his games last year, and he should bounce back  in Indianapolis, where the Colts went 7-1 in 2014.

Prediction ATS: Indianapolis

Season Record: 12-3-1