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Alex Smith spent seven years with the 49ers. Reuters

After Colin Kaepernick led the San Francisco 49ers to the 2013 Super Bowl, the organization realized it was time to trade Alex Smith. One month later, the quarterback was sent to the Kansas City Chiefs for a second-round pick. In just his second game with his new team, Smith will face the club that he played with his entire career.

The Chiefs will host the 49ers on Friday night in Week Two of the preseason at 8 p.m. ET. The game will be shown local in Kansas City on KCTV-5 and in San Francisco on CBS. Viewers can watch a live stream of the contest with a subscription to NFL Preseason Live.

Smith was drafted first overall in 2005, but never had much success until 2011. He became very efficient with the 49ers in the past two years and continued that in his first preseason action with Kansas City. The signal caller completed seven of eight passes for 68 yards. He should play most of the first half, and could have a little extra motivation, even though the game doesn’t count in the standings.

"We're playing my old team and a lot of the guys I played with for a while," Smith said. "It's a preseason game and it's just another step. It's another preseason game and then again it's not."

Smith may have a tougher job moving the ball against a stingy 49ers defense than he originally thought. Jamaal Charles is likely to miss the contest because of a foot strain that he suffered in practice. In the Chiefs 17-13 loss to the New Orleans Saints last week, Charles picked up 13 yards on five rushing attempts.

The 49ers will take the field for the first time after their 10-6 loss to the Denver Broncos in their preseason opener. Kaepernick should get a lot more playing time after throwing only four passes last week. He completed all of his attempts.

Kaepernick will look to find some chemistry with Anquan Boldin. The wide out is still looking for his first catch with San Francisco. The club acquired him from the Baltimore Ravens, shortly after having been defeated in the Super Bowl.

San Francisco will look to integrate their new additions to the defense. Nnamdi Asomugha, Eric Reid and Tank Carradine have been added to the second-best unite in 2012.

Betting Odds: Kansas City-2.5, 40

Prediction: San Francisco 20, Kansas City 7