Tom Cruise and Katie Holmes
Celebrity watchers are tweeting about the Tom Cruise-Katie Holmes split. Reuters

Tom Cruise and Katie Holmes are splitting up after five years of marriage, and celebrity watchers are thinking -- and tweeting -- that the impending divorce must have something to do with the Mission: Impossible star's famously strong ties to the Church of Scientology.

Interested fans and foes are having a field day with the controversial religion on Twitter.

One woman with the handle @ktruly poked fun at Holmes' Dawson's Creek days: Too scared to watch Scientology documentary so I think I'll watch Dawson's Creek instead ?#marriageimpossible3.

A man with the Twitter handle @JungleZebra tweeted about the age each of Cruises's wives were when they moved to divorce him: #tomcruise split with each of his 3 wives when they were 33, an extremely important number in ?#Scientology coincidence? I think not Watson!

Romance author Teresa Medeiros is hoping that Holmes won't be silenced: Please don't let ?#KatieHolmes sign a non-disclosure agreement!'s probably too late, right?

Even talk show host Bill Maher tweeted about the impending divorce: Reading about ?#TomCruise - 3 divorces? I'm beginning to think Operating Thetan Level 7 isn't all its cracked up to be.

Another Twitter user with the handle @zaiger tweeted in favor of Holmes: FREE KATIE HOLMES ?#SCIENTOLOGY ?#CHANOLOGY. (Chanology is a reference to Project Chanology, a movement led by members of Anonymous to oppose Scientology.)

Writer David Wild tweeted that the divorce might have to do with Cruise's new movie, Rock of Ages, which recently flopped in theaters: Wow, apparently ?#KatieHolmes REALLY didn't like Rock Of Ages.

Media mogul Rupert Murdoch, facing his own scandals, surprised his roughly 275,000 followers on Sunday when he threw in his two cents.

Watch Katie Holmes and Scientology story develop, he tweeted on Sunday. Something creepy, maybe even evil, about these people.

Based on his follow-up tweets, it appears Murdoch was deluged with responses -- but he remains unfazed.

Scientology tweet hundreds of attacks, he tweeted. Expect they will increase and get worse and maybe threatening. Still stick to my story.