Mary Tyler Moore Pictures: See Photos Of The Late Actress' Career And Advocacy Work Throughout The Years

Mary Tyler Moore, the actress known for her eponymous 1970s TV show and subsequent activist work for diabetes awareness, died Wednesday. She was 80.

Moore's death triggered an immediate outpouring of sympathies from people like anchor Savannah Guthrie, comedian Stephen Fry and actor Michael Keaton, all of whom posted fond memories of Moore on social media. Mara Buxbaum, Moore's publicist, also expressed her condolences as she announced the news of Moore's death.

"Mary Tyler Moore passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine," Buxbaum wrote in a statement shared by the New York Daily News. "A groundbreaking actress, producer and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile."

Moore starred in "The Mary Tyler Moore Show" from 1970 to 1977. The show made waves at the time because it featured a single woman focused on her career and would go on to win 29 Emmy Awards and three Golden Globes.

"She only wanted to play a great character, and she did so," pop culture expert Jennifer Keishin Armstrong told the New York Times. "Mary had America facing such issues as equal pay, birth control, and sexual independence way back in the ’70s."

Moore would go on to appear in "The Dick Van Dyke Show," "Change of Habit" and "Ordinary People." She wrote two books and even scored a Tony Award, but she devoted much of her time to philanthropy.

In 1999, Moore helped found Broadway Barks, an annual adoption event for cats and dogs, alongside Bernadette Peters. She also served as international chairwoman for the Juvenile Diabetes Research Foundation.

"When I was first diagnosed, I debated about how up front I should be about my diabetes, and whether telling colleagues might hinder my work as an actor. But I also realized that if I did speak out, I might be able to help others better cope and manage their diabetes," she told Medline Plus in 2006. " What continues to give me great hope and optimism is my confidence that, through research, we can find a cure."

Tireless in her work for professional and personal causes, Moore was sure to be missed by fans. See photos of the late star throughout the years below: