“Marvel’s Agents of S.H.I.E.L.D.” is exploring unknown territory in Season 5. The agents are in space, and with space comes aliens. At New York Comic Con, Marvel TV boss Jeph Loeb and Melinda May actress Ming-Na Wen teased what fans could expect in the new episodes.

“Yes, we will have aliens,” Wen confirmed to a small group of reporters, including International Business Times, at New York Comic Con. “We can also mention that there will be some Kree.”

“Some blue people. Kreepers, as we like to refer to them,” Loeb added.

Kree have always been involved in S.H.I.E.L.D. Coulson’s (Clark Gregg) revival after his death in “The Avengers” was thanks to a drug developed from Kree blood, and they’re the alien race who created the Inhumans. They last physically appeared in Season 3 of the ABC drama when Hive was trying to create an Inhuman army.

It isn’t just the aliens who will appear. Their technology will also make trouble. Remember the black monolith that transported Simmons (Elizabeth Henstridge) to Maveth? There will be another monolith in “S.H.I.E.L.D.” Season 5. A white one will take the team to the space station.

The Kree aren’t the only aliens the team will be dealing with. At their NYCC panel, the first 20 minutes of the “Agents of S.H.I.E.L.D.” Season 5 premiere were screened, and the agents have other alien predators to handle. (Spoiler Alert: Major details from the premiere are described below.)

There is a bald man who organizes the capture of the agents, and he doesn’t exactly seem human. Audiences saw the man take off his skin before jumping in the shower. The outline of his real body was distinctly alien and very much what a typical Martian outline would be: big head, skinny limbs.

The team doesn’t see the bald guy, though. Their first alien encounter is with something called Roaches. They’re huge, gross and appear to be inspired by someone’s nightmares of lizards/centipedes/cockroaches. More importantly, however, they’re deadly. A member of the space station’s crew tells Coulson that the Roaches are a problem, but they aren’t the big bad here. Unfortunately, the crew member is killed before he can elaborate on the new threat.

Aliens aren’t the only challenge facing Coulson and the agents. “We’re gonna get to see Agent May try to figure out how to zoom through space. It’s not gonna be like the usual piloting that needs to get done. And there’s stuff in the way,” Loeb teased.

“There is. There’s space stuff,” the actress added.

“So you gotta look out for that or else you’ll go boom. And there’ll be lots to go boom,” the executive producer warned.

It sounds like there will be plenty of time to explore all the new threats. Loeb told reporters that at least the first 10 episodes of Season 5 will be set in space. “We’re affectionately referring to it as Lost in Space. Yes, we will be in space. Where in space is part of the mystery of where we are and how or if they’ll ever get home,” he said.

“Agents of S.H.I.E.L.D.” fans can expect even more mystery this year too. While fans have previously been able to look to the comics for clues about what to anticipate or characters’ true identities, this year will involve more waiting.

“In previous seasons, the audience knows what is going on. … This year, which is something that we’ve never done before is, ‘Boom! They’re in space.’ They don’t know where they are and the mystery of what is going to happen, the audience is going along with them on that,” Loeb explained. “They learn, you learn. It’s one of those things where they’re not catching up. You’re actually with our agents on this adventure.”

“Marvel’s Agents of S.H.I.E.L.D.” Season 5 premieres Friday, Dec. 1 at 8 p.m. EDT on ABC.