Don those surgical gloves and strap on that stethoscope because “Chicago Med” is back with Season 2. New drama, new stories and new characters will be seen at the Gaffney Chicago Medical Center. Last season, Dr. Connor Rhodes lost his mentor, Dr. David Downey, to cancer and Nurse April Sexton’s medical exam revealed that she has tuberculosis.

What will happen in “Chicago Med” Season 2? Here’s everything you need to know:

1. Episode 1 Synopsis

Episode 1 kicks off with several changes taking place at the hospital. The Season 2 premiere begins with Dr. Rhodes (Colin Donnell) commencing his fellowship in cardiothoracic surgery with a new mentor, Dr. Latham (Ato Essandoh). However, the official synopsis reveals that Rhodes gets off on the wrong foot with his challenging new mentor. Will he be able to work for two years with his new boss?

Meanwhile, April (Yaya DaCosta) comes to terms with her recently discovered illness. Will she tell her boyfriend Tate (Deron J. Powell) that she is sick?

However, the good news is that Dr. Ethan Choi (Brian Tee) will be promoted to chief resident but he will soon realize that this job is harder than it seems.

Elsewhere, Dr. Daniel Charles (Oliver Platt) will approach Sarah Reese (Rachel DiPillo) with an interesting opportunity that will catch her off-guard. Despite turning down the offer to work in pathology, Sarah won’t be unemployed. In fact, she will return to “Chicago Med” in Season 2 as a new resident thanks to Dr. Charles.

Additionally, the Season 2 premiere will show Dr. Manning (Torrey DeVitto) treating a pregnant woman with extensive injuries. Her new pregnant patient was recently a victim of a high speed collision.

Chicago Med Dr. Rhodes gets a new challenging mentor, Isidore Latham ( guest star Ato Essandoh), in the Season 2 premiere of “Chicago Med.” Photo: Elizabeth Sisson/NBC

Moreover, “Chicago Med” Season 2, episode 1, will also show Dr. Halstead (Nick Gehlfuss) take exception to the actions of a fourth-year medical student named Jeff Clarke (Jeff Hephner). Clarke has a history with Dr. Manning which could be the reason behind Dr. Halstead’s behavior towards him.

Season 2 also begins with Sharon Goodwin (S. Epatha Merkerson) being single and ready to mingle.

2. Episode Titles

NBC released the titles of the first couple of episodes of “Chicago Med.” They are:

Episode 1 – “Soul Care”

Episode 2 – “Natural History”

Episode 3 – “Win Loss”

Episode 4 – “Brother’s Keeper”

3. New Characters

Apart from “Chicago Fire” alum Jeff Hephner starring in “Chicago Med” as a fourth-year medical student named Jeff Clarke and Essandoh starring as Dr. Latham, Season 2 will also see the addition of Mekia Cox as Dr. Charles’ eldest daughter, Robin. An epidemiologist by profession, Robin has a complicated relationship with her father and she is called to the hospital in episode 4 to assist in a complicated case.

4. A Love Interest For Dr. Rhodes

Smart and rebellious Robin will become Dr. Rhodes’ new love interest, However, her father is not pleased with her new boyfriend. Charles is not sure if Rhodes has the ability to have a healthy relationship since he hasn’t seen one in his childhood. It’s safe to say that this new relationship will be a complicated one.

5. April’s Tuberculosis Diagnosis

April is going to have a huge storyline in “Chicago Med” Season 2. She will avoid Tate and her son because she is worried that they will contract TB even though her disease is latent. Just when she is convinced that it isn’t latent, her illness becomes active and contagious. The question is whether she will tell Tate of her sickness or whether he find out about it on his own.

Don’t miss the Season 2 premiere of “Chicago Med” on Thursday, Sept. 22 at 9 p.m. EDT on NBC.