There are at least 189,479 cases of coronavirus in the United States, with the domestic death toll at 4,078 as of Wednesday at 10:40 a.m. ET. As the coronavirus continues to spread across the country, President Trump has said the next two weeks will be “very painful.”

“This is going to be a rough two-week period,” Trump said at a White House press briefing Tuesday. “When you look at night the kind of death that has been caused by this invisible enemy, it’s incredible.”

New York has the largest number of infected in the United States, with 76,049 cases and 1,714 deaths. The state has urged the federal government for more ventilators and other medical supplies.

“I’m tired of being behind this virus. We’ve been behind this virus from day one,” New York Gov. Andrew Cuomo said Tuesday. “We underestimated this virus. It’s more powerful, it’s more dangerous than we expected.”

New Jersey comes in second, with 18,997 cases and 267 deaths. California has the third-highest number of cases, with 8,558 infected and 182 deaths.

Trump has issued a national emergency order in response to the outbreak. The White House has also extended its social distancing guidelines through the end of the month as states across the country shut down non-essential businesses and services to keep cases from rising.

The pandemic has claimed over 42,000 deaths and more than 850,000 infections worldwide.