The Knick
Dr. Edwards (Andre Holland, left) hopes to take over for Dr. Thackery (Clive Owen, right) while the latter is in rehab in the premiere of "The Knick" Season 2. Pictured: Edwards and Thackery in Season 1. Cinemax

Fresh off an Emmy nomination, Clive Owen will return to television in October reprising the role of Dr. John Thackery in Season 2 of "The Knick" on Cinemax. The turn-of-the-century medical drama, directed by Steven Soderbergh ("Magic Mike," "Haywire"), ended Season 1 with fans unsure if Thackery, who had become increasingly addicted to cocaine, would ever return to practice medicine in the Knickerbocker Hospital, let alone if there would even be a Knick for him to come back to. The synopsis for the Season 2 premiere, released by Cinemax in a press release Monday, reveals that some big changes lie ahead for the hospital.

According to the synopsis, the Knick is on the move. The hospital was riddled with financial problems in Season 1, so the idea had been raised in a board meeting to move it uptown. While Thackery had protested that the hospital belongs downtown where it can serve the average New Yorker, it seems that while he is missing in action the hospital will indeed be relocated.

There might also be new leadership at the Knick. In the Season 1 finale, Thackery was checked into a rehab facility to nurse his cocaine addiction and the cliff-hanger that the facility was using heroin to treat his disease cast some doubt on the speediness of his return. In his absence, Dr. Edwards (Andre Holland) wants to take over as chief of surgery. While Edwards has been slowly and steadily rising through the ranks of the Knick staff and gaining Thackery's confidence, the idea of an African-American chief of surgery will be a tough pill to swallow for some, including Dr. Gallinger (Eric Johnson), who will apparently refuse to return from his suspension if under Edwards' supervision.

Meanwhile, fans will remember that, against Thackery’s recommendation, Barrow (Jeremy Bobb) made a big mistake in enlisting Wu (Perry Yung), Thackery’s mysterious opium dealer, to kill Bunky Collier (Danny Hoch) after getting too far in debt. Wu did the job, but then informed Barrow that he would be It seems Wu is cashing in on his favor in the premiere, demanding free medical exams for all his prostitutes. What could go wrong?

Watch the promo for Season 2 below:

Will Dr. Edwards become chief of surgery at the Knick? Fans will have to wait to find out. "The Knick" Season 2 premieres Friday, Oct. 16, at 10 p.m. EDT on Cinemax.