St. Petersburg, Fl., is apparently the saddest city in America, with Detroit, Mi. not far behind, according to a study by Men's Health magazine, which used data such as unemployment and suicid rates, antidepressant usage and the number of people who actually admitted to depression.

The study ranked Memphis, Tn. third, with Tampa, Fl. and Louisville, Ky. in fourth and fifth, respectively. St. Louis, Mo., Birmingham, Al., Miami, Fl., Reno, Nv. and Las Vegas, Nv. are the other cities in the top ten.

Also according to the list, Honolulu, Hi., came in as the happiest city in the U.S., followed by Manchester U.S. Honolulu came in as the happiest city in the U.S closely followed by Manchester, N.H., Fargo, N.D., Omaho, Ne., and Boston, Ma.

Issues such as suicide, unemployment and rising depression rates are getting a lot of prominence right now, especially since the U.S. is facing concerns regarding its economy. Earlier studies have shown that most country's suicide rate rises and falls in relation to how well the economy is doing. For example, the biggest increase in suicides occurred in the period of the Great Depression, when the national rate jumped from 18 per 100,000 adults in 1928 to more than 22 per 100,000 people in 1932.

Depression is a chronic illness that exacts a significant toll on America's health and productivity. It affects more than 21 million American children and adults annually and is the leading cause of disability in the United States for individuals aged 15 to 44.