Fans were finally handed the answers to big questions about Barbara Morgan and why Jon took his own life on the Season One finale of “A Million Little Things,” but a whole new host of questions will need to be answered as the ABC drama returns for Season 2.

In just one week, the series will be returning for its sophomore season, and things are set to pick up where they left off in the previous finale. Fans will not only see the aftermath of Eddie’s (David Giuntoli) confession to Katherine (Grace Park) that he is the father of Delilah’s (Stephanie Szostak) baby, but also several other moments unfolding in the friends’ lives as they continue to move past Jon’s (Ron Livingston) suicide and the secrets he had been keeping in regards to Barbara Morgan (Drea De Matteo).

So what will fans see unfold in the new season? According to the synopsis for the Season 2 premiere, “Coming Home,” the drama between Eddie, Katherine and Delilah won’t be the only thing that unfolds.

A Million little things Maggie (Allison Bloom) and Gary (James Roday) will face some new problems on the Season 2 premiere of “A Million Little Things.” Photo: ABC/David Bukach

“Gary and Maggie struggle with living together post-cancer,” the synopsis reads.

Gary (James Roday) and Maggie (Allison Miller) overcame a large obstacle when she managed to survive after surgery and chemo to treat her breast cancer—and they were both ready to take the next step in their relationship as a result. However, Roday told TV Line that the couple is quickly going to realize they don’t know one another as well as they thought since their lives were so consumed by her cancer diagnosis before.

“I think these two probably don’t know each other as well as they think they do,” he said. “How could they? The relationship was defined exclusively by keeping her alive. But once you beat something like that, there’s a euphoria where you feel like, ‘We can conquer anything because we just conquered cancer.’ So yeah, they probably jumped the gun. And now they’re having to reverse-engineer all of the steps in a relationship that got skipped.”

However, Rome (Romany Falco) and Regina (Christina Moses) will also be dealing with their own problems, with the synopsis stating that “Rome and Regina continue to be at odds about having a baby of their own.”

“A Million Little Things” Season 2 premieres Thursday, Sept. 26 at 9 p.m. EDT on ABC.