Christina Applegate Talks 'Last' Awards Show, 40-Pound Weight Gain After MS Diagnosis

Christina Applegate is opening up about wrapping the third and final season of "Dead to Me" and attending what could be her "last" awards show as an actor following her multiple sclerosis diagnosis.

The third season of the Netflix series debuted in November 2022, more than two years after Season 2 premiered, due to Applegate's diagnosis during filming.

In a new interview, Applegate, who first publicly shared her diagnosis in 2021, told The Los Angeles Times that she was able to shoot the final season with the support of her "Dead to Me" co-star Linda Cardellini.

Applegate, 51, said Cardellini, 47, "literally pulled [her] under her wing and protected [her], and took care of [her] every single day" during filming.

"Also the tables were turned: [Applegate's character] Jen is taking care of her friend who's dying, yet Linda was taking care of me as I was saying goodbye to the person that I'd always known — so part of me was dying," she told the publication.

Applegate's efforts to finish the series paid off as she's nominated for outstanding performance by a female actor in a comedy series in the upcoming 2023 Screen Actors Guild Awards for her leading role in the dark comedy.

She revealed that she plans to attend the ceremony with her 12-year-old daughter Sadie later this month but said it will "probably" be her final awards show as an actor.

"It's my last awards show as an actor probably, so it's kind of a big deal," she told the L.A. Times. "Right now, I couldn't imagine getting up at 5 a.m. and spending 12 to 14 hours on a set; I don't have that in me at this moment."

As for her future plans, Applegate said she is considering "doing a s— ton of voice-overs to make some cash to make sure that my daughter's fed and we're homed."

The actress also admitted that she waited months before watching the final 10 episodes of "Dead to Me" and that she had to stop periodically when it became too painful.

"I don't like seeing myself struggling," she explained, before adding, "Also, I gained 40 pounds because of inactivity and medications, and I didn't look like myself, and I didn't feel like myself."

She continued, "At some point, I was able to distance myself from my own ego, and realize what a beautiful piece of television it was. All the scenes I wasn't in were so much fun to see and experience for the very first time."

Last month, Applegate clapped back at a troll who accused her of getting "bad" plastic surgery following the changes in her appearance amid her multiple sclerosis battle.

"MS didn't make you look that way a plastic surgeon did," the troll wrote to Applegate. "And you are a scammer and are not (Christina) Applegate."

"And a bad plastic surgeon at that," the user added.

Applegate shared via Twitter a screenshot of the troll's message. She explained that the exchange took place after the user commented about her appearance on a People magazine article, and she DMed the critic and told them their remark "wasn't nice."

"Sooooo I made the unfortunate decision to look at some comments on an article from people mag [sic] about me and my kids at the CCA," the actress tweeted. "Of course I told her that it wasn't nice. This was her reply. What is wrong with people? By the way, I laughed."