The Senate is expected to overturn President Joe Biden's executive order that mandates businesses with 100 or more employees to get vaccinated or require weekly testing and mask mandates in a bipartisan vote that may take place as early as Wednesday.

Democrat Sens. Jon Tester of Montana and Joe Manchin of West Virginia will join Republicans who will look to repeal the president’s precautionary measure, with Sen. Mike Braun, R-Ind., leading the effort.

The Congressional Review Act (CRA) allows the minority party to force a vote on a resolution to disapprove of a federal rule.

Manchin had previously voiced his disagreement with the president's decision.

"I don’t think the government has to make every decision for the private sector," Manchin said Tuesday at The Wall Street Journal’s CEO Council Summit.

"I have long said we should incentivize, not penalize, private employers whose responsibility it is to protect their employees from COVID-19,” Manchin said.

Tester has said he opposes the mandate because he believes it is bad for the business community of Montana.

Braun expressed confidence that he can get the resolution to pass. In an interview with MSNBC, Braun said he had spoken to up to four swing-state Democrats who may oppose the mandate.

Biden says he would veto the resolution, which would be the first of his presidency. White House Press Secretary Jen Psaki says the administration is prepared to "stand up" to the anti-vaccine crowd.