Acclaimed filmmaker Martin Scorsese goes back to his crime film roots with Robert DeNiro, Joe Pesci and Al Pacino in the first trailer for his latest film, “The Irishman.”

Based on the book “I Heard You Paint Houses,” “The Irishman” follows the life of infamous hitman Frank “The Irishman” Sheeran. Sheeran was a World War II veteran who became a hitman for the Bufalino Crime Family before becoming a union leader for the Teamsters alongside Jimmy Hoffa. The film will focus on this time, specifically, and Sheeran’s alleged involvement in Hoffa’s disappearance.

The first trailer offers a glimpse of that life and how Sheeran played a pivotal, but hidden, role in the world of organized crime throughout the 1960s and 1970s. It also offers a first glimpse at the de-aging process applied to DeNiro, who plays the titular hitman. Along with DeNiro, the trailer offers a first look at Pesci’s portrayal of Russell Bufalino and Pacino as Jimmy Hoffa, who make up the three protagonists of the film.

It is the first crime film Scorsese has directed since 2006’s “The Departed” and is the first film he has done with both DeNiro and Pesci since "Casino" in 1995. While DeNiro had remained active since then, Pesci has only done five films since “Casino,” most notably 1998’s “Lethal Weapon 4” and 2006’s “The Good Shepherd.” This will marks the first time Scorsese has directed Pacino.

Scorcese's last big hit was "The Wolf of Wall Street," which made $392 million at the box office and had a 79% rating on Rotten Tomatoes. Scorsese was nominated for Best Director and the film received a Best Picture nomination.

“The Irishman” will debut at the New York Film Festival on Sept. 27, and will have a limited theatrical run before being released on Netflix before the end of 2019.

Robert De Niro attends the Tribeca Film Festival in New York City in 2015. This year’s festival runs April 13-24. De Niro is facing accusations of censorship from the director of an anti-vaccination film pulled from the lineup. Grant Lamos IV/Getty